GGNBP2 (gametogenetin binding protein 2)

2007-02-01  

Identity

HGNC
GGNBP2
LOCATION
17q12
LOCUSID
79893
ALIAS
DIF-3,DIF3,LCRG1,LZK1,ZFP403,ZNF403
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79893
MIM: 612275
HGNC: 19357
Ensembl: ENSG00000278311

Variants:

dbSNP: 79893
ClinVar: 79893
TCGA: ENSG00000278311
COSMIC: GGNBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000278311ENST00000611219A0A087X0E5
ENSG00000278311ENST00000613102Q9H3C7
ENSG00000278311ENST00000615952A0A087X1N0
ENSG00000278311ENST00000616019A0A087X1D7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
317974272020Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells.3
331251302020Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.2
317974272020Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells.3
331251302020Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.2
304505302019GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation.10
304505302019GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation.10
288641312017ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer.9
288641312017ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer.9
273578122016GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor α activity in breast cancer cells.9
273578122016GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor α activity in breast cancer cells.9
248421572014Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.12
248421572014Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.12
223508152012Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.8
223508152012Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.8
151455232004Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930.6

Citation

Dessen P

GGNBP2 (gametogenetin binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45910/js/lib/img/cancer-prone-explorer/