BCAT1 (branched chain amino acid transaminase 1)

2007-02-01  

Identity

HGNC
BCAT1
LOCATION
12p12.1
LOCUSID
586
ALIAS
BCATC,BCT1,ECA39,MECA39,PNAS121,PP18
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 586
MIM: 113520
HGNC: 976
Ensembl: ENSG00000060982

Variants:

dbSNP: 586
ClinVar: 586
TCGA: ENSG00000060982
COSMIC: BCAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060982ENST00000261192P54687
ENSG00000060982ENST00000261192A0A024RAV0
ENSG00000060982ENST00000342945P54687
ENSG00000060982ENST00000538118P54687
ENSG00000060982ENST00000539282P54687
ENSG00000060982ENST00000539780P54687
ENSG00000060982ENST00000546285F5H2F2
ENSG00000060982ENST00000612790A0A087WYF2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Valine, leucine and isoleucine degradationKEGGko00280
Valine, leucine and isoleucine biosynthesisKEGGko00290
Pantothenate and CoA biosynthesisKEGGko00770
Valine, leucine and isoleucine degradationKEGGhsa00280
Valine, leucine and isoleucine biosynthesisKEGGhsa00290
Pantothenate and CoA biosynthesisKEGGhsa00770
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Leucine degradation, leucine => acetoacetate + acetyl-CoAKEGGhsa_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoAKEGGM00036
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Branched-chain amino acid catabolismREACTOMER-HSA-70895

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
377692062024Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression.0
383092892024Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma.0
383401632024High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response.0
383694712024HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.0
377692062024Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression.0
383092892024Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma.0
383401632024High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response.0
383694712024HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.0
363447542023BCAT1, as a prognostic factor for HCC, can promote the development of liver cancer through activation of the AKT signaling pathway and EMT.5
363447542023BCAT1, as a prognostic factor for HCC, can promote the development of liver cancer through activation of the AKT signaling pathway and EMT.5
349848492022BCAT1: A risk factor in multiple cancers based on a pan-cancer analysis.14
352906642022Detection of recurrent colorectal cancer with high specificity using a reporting threshold for circulating tumor DNA methylated in BCAT1 and IKZF1.6
361115722022BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation.2
361236162022Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer.4
362609952022BCAT1 redox function maintains mitotic fidelity.5

Citation

Dessen P

BCAT1 (branched chain amino acid transaminase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45917/favicon/js/lib/cancer-prone-explorer/