SAT1 (spermidine/spermine N1-acetyltransferase 1)

2007-02-01  

Identity

HGNC
SAT1
LOCATION
Xp22.11
LOCUSID
6303
ALIAS
DC21,KFSD,KFSDX,SAT,SSAT,SSAT-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6303
MIM: 313020
HGNC: 10540
Ensembl: ENSG00000130066

Variants:

dbSNP: 6303
ClinVar: 6303
TCGA: ENSG00000130066
COSMIC: SAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130066ENST00000379251A6NJE6
ENSG00000130066ENST00000379253A6NM56
ENSG00000130066ENST00000379254E9PD37
ENSG00000130066ENST00000379270P21673
ENSG00000130066ENST00000379270A0A384NQ10

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
GABA biosynthesis, eukaryotes, putrescine => GABAKEGGhsa_M00135
GABA biosynthesis, eukaryotes, putrescine => GABAKEGGM00135
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Interconversion of polyaminesREACTOMER-HSA-351200
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369075042023MYC-driven U2SURP regulates alternative splicing of SAT1 to promote triple-negative breast cancer progression.2
369075042023MYC-driven U2SURP regulates alternative splicing of SAT1 to promote triple-negative breast cancer progression.2
359778082022Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus.5
359778082022Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus.5
346581002021ASMTL-AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis.13
346581002021ASMTL-AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis.13
312830072020Identification of TAF1, SAT1, and ARHGEF9 as DNA methylation biomarkers for hepatocellular carcinoma.13
324327212020Dengue virus targets RBM10 deregulating host cell splicing and innate immune response.33
312830072020Identification of TAF1, SAT1, and ARHGEF9 as DNA methylation biomarkers for hepatocellular carcinoma.13
324327212020Dengue virus targets RBM10 deregulating host cell splicing and innate immune response.33
313520092019Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression.7
313996462019Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness.19
313520092019Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression.7
313996462019Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness.19
279014752017Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/β-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.31

Citation

Dessen P

SAT1 (spermidine/spermine N1-acetyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45929