CRTAM (cytotoxic and regulatory T cell molecule)

2007-02-01  

Identity

HGNC
CRTAM
LOCATION
11q24.1
LOCUSID
56253
ALIAS
CD355
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56253
MIM: 612597
HGNC: 24313
Ensembl: ENSG00000109943

Variants:

dbSNP: 56253
ClinVar: 56253
TCGA: ENSG00000109943
COSMIC: CRTAM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109943ENST00000227348O95727
ENSG00000109943ENST00000533709O95727

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
383545092024CRTAM promotes antitumor immune response in triple negative breast cancer by enhancing CD8+ T cell infiltration.0
383545092024CRTAM promotes antitumor immune response in triple negative breast cancer by enhancing CD8+ T cell infiltration.0
323009142020Prokaryotic Expression of the Immunoglobulin's Domains of CRTAM to Characterize a Monoclonal Antibody.1
323009142020Prokaryotic Expression of the Immunoglobulin's Domains of CRTAM to Characterize a Monoclonal Antibody.1
307911482019CRTAM(+) NK cells endowed with suppressor properties arise in leukemic bone marrow.7
307911482019CRTAM(+) NK cells endowed with suppressor properties arise in leukemic bone marrow.7
266949682016CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.91
266949682016CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.91
259109592015CRTAM is negatively regulated by ZEB1 in T cells.5
259109592015CRTAM is negatively regulated by ZEB1 in T cells.5
235301482013CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated Vγ9Vδ2 T cells.7
238273832013A genome-wide association study for malignant mesothelioma risk.18
238714862013Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and nectin-like 2.6
235301482013CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated Vγ9Vδ2 T cells.7
238273832013A genome-wide association study for malignant mesothelioma risk.18

Citation

Dessen P

CRTAM (cytotoxic and regulatory T cell molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45934/teaching-explorer/cancer-prone-explorer/css/card-gene.css