SST (somatostatin)

2007-02-01  

Identity

HGNC
SST
LOCATION
3q27.3
LOCUSID
6750
ALIAS
SMST,SST1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6750
MIM: 182450
HGNC: 11329
Ensembl: ENSG00000157005

Variants:

dbSNP: 6750
ClinVar: 6750
TCGA: ENSG00000157005
COSMIC: SST

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157005ENST00000287641P61278

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
hypothalamus
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368348602023Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes.2
370734882023The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons.6
368348602023Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes.2
370734882023The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons.6
350210882022Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits.16
350650982022Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity.5
351633742022Role of Somatostatin Signalling in Neuroendocrine Tumours.13
363617902022Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin.2
350210882022Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits.16
350650982022Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity.5
351633742022Role of Somatostatin Signalling in Neuroendocrine Tumours.13
363617902022Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin.2
326115162021Metastatic pancreatic neuroendocrine tumors have decreased somatostatin expression and increased Akt signaling.5
340707852021Somatostatin, a Presynaptic Modulator of Glutamatergic Signal in the Central Nervous System.10
343186832021LINC01133 hampers the development of gastric cancer through increasing somatostatin via binding to microRNA-576-5p.6

Citation

Dessen P

SST (somatostatin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45942/js/favicon/css/card-gene.css