Identity
HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
NPHS14,S1PL,SPL
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8879
MIM: 603729
HGNC: 10817
Ensembl: ENSG00000166224
Variants:
dbSNP: 8879
ClinVar: 8879
TCGA: ENSG00000166224
COSMIC: SGPL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000166224 | ENST00000299297 | H7BXL7 |
| ENSG00000166224 | ENST00000373202 | O95470 |
| ENSG00000166224 | ENST00000409118 | H0Y3V8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35748945 | 2023 | A rare cause of nephrotic syndrome-sphingosine-1-phosphate lyase (SGPL1) deficiency: 6 cases and a review of the literature. | 2 |
| 36050428 | 2023 | SGPL1 Deficiency: Nephrotic Syndrome with Lymphopenia. | 1 |
| 36834691 | 2023 | Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation. | 1 |
| 35748945 | 2023 | A rare cause of nephrotic syndrome-sphingosine-1-phosphate lyase (SGPL1) deficiency: 6 cases and a review of the literature. | 2 |
| 36050428 | 2023 | SGPL1 Deficiency: Nephrotic Syndrome with Lymphopenia. | 1 |
| 36834691 | 2023 | Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation. | 1 |
| 32971566 | 2021 | S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells. | 6 |
| 33730651 | 2021 | Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response. | 6 |
| 34073605 | 2021 | S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3. | 3 |
| 34085165 | 2021 | Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. | 5 |
| 32971566 | 2021 | S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells. | 6 |
| 33730651 | 2021 | Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response. | 6 |
| 34073605 | 2021 | S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3. | 3 |
| 34085165 | 2021 | Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. | 5 |
| 31455837 | 2020 | SGPL1(321) mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma. | 5 |
Citation
Dessen P
SGPL1 (sphingosine-1-phosphate lyase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45944/sgpl1
