OXT (oxytocin/neurophysin I prepropeptide)

2007-02-01  

Identity

HGNC
OXT
LOCATION
20p13
LOCUSID
5020
ALIAS
OT,OT-NPI,OXT-NPI

Other Information

Locus ID:

NCBI: 5020
MIM: 167050
HGNC: 8528
Ensembl: ENSG00000101405

Variants:

dbSNP: 5020
ClinVar: 5020
TCGA: ENSG00000101405
COSMIC: OXT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101405ENST00000217386P01178
ENSG00000101405ENST00000217386X5D7M6

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Vasopressin-like receptorsREACTOMER-HSA-388479
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
hypothalamus
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374603652024Oxytocin: physiology, pharmacology, and clinical application for labor management.3
377212152024The impact of childhood trauma exposure on social functioning in schizophrenia: the moderated mediation role of oxytocin and oxytocin receptor gene polymorphisms.1
378569262024Genetic variability in the oxytocin system is linked to individual differences in cuddliness among human infants.0
379932872024From love to pain: is oxytocin the key to grief complications?0
380486542024The interplay of childhood trauma, oxytocin, and impulsivity in predicting the onset of methamphetamine use.0
381011842024Oxytocin as a transdiagnostic biomarker of well-being in severe mental illness during the Covid-19 pandemic.0
381576672024Decreased oxytocin plasma levels and oxytocin receptor expression associated with aggressive behavior in aggressive-impulsive disorders.1
382287032024Peripheral oxytocin levels are linked to hypothalamic gray matter volume in autistic adults: a cross-sectional secondary data analysis.1
382429692024Neural and behavioral evidence for oxytocin's facilitatory effects on learning in volatile and stable environments.0
383967412024The Pivotal Role of Oxytocin's Mechanism of Thermoregulation in Prader-Willi Syndrome, Schaaf-Yang Syndrome, and Autism Spectrum Disorder.0
385221512024Group differences in OXT methylation between patients with Major Depressive Disorder and healthy controls: A pre-registered replication study.0
374603652024Oxytocin: physiology, pharmacology, and clinical application for labor management.3
377212152024The impact of childhood trauma exposure on social functioning in schizophrenia: the moderated mediation role of oxytocin and oxytocin receptor gene polymorphisms.1
378569262024Genetic variability in the oxytocin system is linked to individual differences in cuddliness among human infants.0
379932872024From love to pain: is oxytocin the key to grief complications?0

Citation

Dessen P

OXT (oxytocin/neurophysin I prepropeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45947