FCER1A (Fc fragment of IgE receptor Ia)

2007-02-01  

Identity

HGNC
FCER1A
LOCATION
1q23.2
LOCUSID
2205
ALIAS
FCE1A,FcERI

Other Information

Locus ID:

NCBI: 2205
MIM: 147140
HGNC: 3609
Ensembl: ENSG00000179639

Variants:

dbSNP: 2205
ClinVar: 2205
TCGA: ENSG00000179639
COSMIC: FCER1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179639ENST00000368114E9PRN1
ENSG00000179639ENST00000368115P12319

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164776964desloratadineChemicalClinicalAnnotationassociatedPD25412950
PA166129535mizolastineChemicalClinicalAnnotationassociatedPD25412950
PA445999UrticariaDiseaseClinicalAnnotationassociatedPD25412950

References

Pubmed IDYearTitleCitations
363680132023Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells.1
363680132023Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells.1
364303782022The Crosstalk between FcεRI and Sphingosine Signaling in Allergic Inflammation.5
364303782022The Crosstalk between FcεRI and Sphingosine Signaling in Allergic Inflammation.5
331609672021Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells.3
344204842021Genetic association study of CTLA4 and FCεRIα polymorphisms in asthmatic patients in the southwestern region of Iran.1
349253392021FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease.8
331609672021Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells.3
344204842021Genetic association study of CTLA4 and FCεRIα polymorphisms in asthmatic patients in the southwestern region of Iran.1
349253392021FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease.8
327517342020FcεRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes.12
328835462020Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis.5
331387972020Prediction of prognostic signatures in triple-negative breast cancer based on the differential expression analysis via NanoString nCounter immune panel.7
327517342020FcεRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes.12
328835462020Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis.5

Citation

Dessen P

FCER1A (Fc fragment of IgE receptor Ia)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45948