PLSCR1 (phospholipid scramblase 1)

2007-02-01  

Identity

HGNC
PLSCR1
LOCATION
3q24
LOCUSID
5359
ALIAS
MMTRA1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5359
MIM: 604170
HGNC: 9092
Ensembl: ENSG00000188313

Variants:

dbSNP: 5359
ClinVar: 5359
TCGA: ENSG00000188313
COSMIC: PLSCR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188313ENST00000342435O15162
ENSG00000188313ENST00000448787O15162
ENSG00000188313ENST00000462666C9J9P4
ENSG00000188313ENST00000463777F2Z3F2
ENSG00000188313ENST00000468985F2Z3F2
ENSG00000188313ENST00000472349C9JE06
ENSG00000188313ENST00000478267F2Z3F2
ENSG00000188313ENST00000483300H7C5I5
ENSG00000188313ENST00000486631C9J0H3
ENSG00000188313ENST00000487389C9J7K9
ENSG00000188313ENST00000488253F2Z3F2
ENSG00000188313ENST00000489775F2Z3F2
ENSG00000188313ENST00000493432F2Z3F2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386366892024Phospholipid scramblase 1 acts through the IL-6/JAK/STAT3 pathway to promote the malignant progression of glioma.0
388665222024Phospholipid Scramblase 1 Localizes Proximal to Sphingomyelin Synthase Isoforms but Is Not Involved in Sphingomyelin Synthesis.0
386366892024Phospholipid scramblase 1 acts through the IL-6/JAK/STAT3 pathway to promote the malignant progression of glioma.0
388665222024Phospholipid Scramblase 1 Localizes Proximal to Sphingomyelin Synthase Isoforms but Is Not Involved in Sphingomyelin Synthesis.0
374385302023PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.5
374385302023PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.5
346512492022The ratio of ATP11C/PLSCR1 mRNA transcripts has clinical significance in sickle cell anemia.1
347733352022Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.7
351381192022The Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus.3
354394772022Interaction of human phospholipid scramblase 1 with cholesterol via CRAC motif is essential for functional regulation and subcellular localization.0
362601462022Biophysical characterization of the DNA binding motif of human phospholipid scramblase 1.0
346512492022The ratio of ATP11C/PLSCR1 mRNA transcripts has clinical significance in sickle cell anemia.1
347733352022Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1-STAT1 loop in lung adenocarcinoma.7
351381192022The Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus.3
354394772022Interaction of human phospholipid scramblase 1 with cholesterol via CRAC motif is essential for functional regulation and subcellular localization.0

Citation

Dessen P

PLSCR1 (phospholipid scramblase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45949