CBR3 (carbonyl reductase 3)

CBR3 (carbonyl reductase 3)

2007-02-01 Affiliation

Identity

HGNC

LOCATION

21q22.12

LOCUSID

ALIAS

HEL-S-25,SDR21C2,hCBR3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 874
MIM: 603608
HGNC: 1549
Ensembl: ENSG00000159231

Variants:

dbSNP: 874
ClinVar: 874
TCGA: ENSG00000159231
COSMIC: CBR3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159231	ENST00000290354	O75828
ENSG00000159231	ENST00000290354	V9HW40

Expression (GTEx)

0

10

20

30

40

50

60

70

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Arachidonic acid metabolism	KEGG	hsa00590
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA128406956	fluorouracil	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD
PA130620651	anthracyclines and related substances	Chemical	ClinicalAnnotation	associated		PD	18457324
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	18551042
PA444370	Heart Failure	Disease	ClinicalAnnotation	associated		PD	18457324
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated		PD	18457324
PA445113	Neutropenia	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	18551042
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD
PA449212	daunorubicin	Chemical	VariantAnnotation	associated	PK		20007405
PA449412	doxorubicin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	associated	PK	PD	18551042, 20007405, 21048526
PA449476	epirubicin	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
32945466	2020	Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of non‑small‑cell lung cancer by sponging microRNA‑509‑3p and competitively upregulating HDAC9 expression.	13
32945466	2020	Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of non‑small‑cell lung cancer by sponging microRNA‑509‑3p and competitively upregulating HDAC9 expression.	13
30096220	2018	PlncRNA-1 is overexpressed in retinoblastoma and regulates retinoblastoma cell proliferation and motility through modulating CBR3.	9
30125887	2018	NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP.	1
30096220	2018	PlncRNA-1 is overexpressed in retinoblastoma and regulates retinoblastoma cell proliferation and motility through modulating CBR3.	9
30125887	2018	NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP.	1
26563179	2016	Risk factors for anthracycline-associated cardiotoxicity.	21
26799497	2016	Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.	38
26563179	2016	Risk factors for anthracycline-associated cardiotoxicity.	21
26799497	2016	Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.	38
22001310	2012	A conserved antioxidant response element (ARE) in the promoter of human carbonyl reductase 3 (CBR3) mediates induction by the master redox switch Nrf2.	4
22124095	2012	Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.	142
22360420	2012	Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.	24
22425771	2012	Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli.	3
22527884	2012	Genetic variation in the carbonyl reductase 3 gene confers risk of type 2 diabetes and insulin resistance: a potential regulator of adipogenesis.	6

Citation

Dessen P

CBR3 (carbonyl reductase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45951/js/lib/bootstrap.min.js