GZMB (granzyme B)

2007-02-01  

Identity

HGNC
GZMB
LOCATION
14q12
LOCUSID
3002
ALIAS
C11,CCPI,CGL-1,CGL1,CSP-B,CSPB,CTLA1,CTSGL1,HLP,SECT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3002
MIM: 123910
HGNC: 4709
Ensembl: ENSG00000100453

Variants:

dbSNP: 3002
ClinVar: 3002
TCGA: ENSG00000100453
COSMIC: GZMB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100453ENST00000216341P10144
ENSG00000100453ENST00000382540J3KPK2
ENSG00000100453ENST00000382542J3KPK2
ENSG00000100453ENST00000415355J3KQ52
ENSG00000100453ENST00000526004E9PRD7
ENSG00000100453ENST00000530830E9PLX4
ENSG00000100453ENST00000532263E9PID1
ENSG00000100453ENST00000554242E9PRD7
ENSG00000100453ENST00000616551Q6XGZ2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Type I diabetes mellitusKEGGko04940
Autoimmune thyroid diseaseKEGGko05320
Allograft rejectionKEGGko05330
Graft-versus-host diseaseKEGGko05332
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
Type I diabetes mellitusKEGGhsa04940
Autoimmune thyroid diseaseKEGGhsa05320
Allograft rejectionKEGGhsa05330
Graft-versus-host diseaseKEGGhsa05332
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH2REACTOMER-HSA-1980145
NOTCH2 intracellular domain regulates transcriptionREACTOMER-HSA-2197563
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation, myristolyation of BID and translocation to mitochondriaREACTOMER-HSA-75108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380006772024Molecular and clinicopathological features of granzyme B-negative extranodal NK/T-cell lymphoma.0
383745662024Granzyme B is elevated in esophageal biopsies from children with eosinophilic esophagitis.0
380006772024Molecular and clinicopathological features of granzyme B-negative extranodal NK/T-cell lymphoma.0
383745662024Granzyme B is elevated in esophageal biopsies from children with eosinophilic esophagitis.0
363318262023Granzyme B: A novel therapeutic target for treatment of atopic dermatitis.2
368307572023Granzyme B in Autoimmune Skin Disease.6
368490372023Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration Through Proteolysis of Thrombospondin-1.4
370715332023NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection.2
370745312023Human granzyme B binds Plasmodium falciparum Hsp70-x and mediates antiplasmodial activity in vitro.0
371960652023Clonally expanded, thyrotoxic effector CD8(+) T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis.6
372470832023A robust gene prognostic index composed of GZMB, IRF1, and TP63 can stratify the risk of two metastatic urothelial carcinoma cohorts based on immune checkpoint blockade therapy.0
374708182023The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4(+) T cells.0
380728402023Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?0
363318262023Granzyme B: A novel therapeutic target for treatment of atopic dermatitis.2
368307572023Granzyme B in Autoimmune Skin Disease.6

Citation

Dessen P

GZMB (granzyme B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45957/gzmb-(granzyme-b)