GLUL (glutamate-ammonia ligase)

2007-02-01  

Identity

HGNC
GLUL
LOCATION
1q25.3
LOCUSID
2752
ALIAS
GLNS,GS,PIG43,PIG59
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2752
MIM: 138290
HGNC: 4341
Ensembl: ENSG00000135821

Variants:

dbSNP: 2752
ClinVar: 2752
TCGA: ENSG00000135821
COSMIC: GLUL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135821ENST00000311223P15104
ENSG00000135821ENST00000311223A8YXX4
ENSG00000135821ENST00000331872P15104
ENSG00000135821ENST00000331872A8YXX4
ENSG00000135821ENST00000339526P15104
ENSG00000135821ENST00000339526A8YXX4
ENSG00000135821ENST00000417584P15104
ENSG00000135821ENST00000417584A8YXX4
ENSG00000135821ENST00000642379A0A2R8YDT1

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Glyoxylate and dicarboxylate metabolismKEGGko00630
Nitrogen metabolismKEGGko00910
Arginine biosynthesisKEGGhsa00220
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Nitrogen metabolismKEGGhsa00910
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter uptake and Metabolism In Glial CellsREACTOMER-HSA-112313
Astrocytic Glutamate-Glutamine Uptake And MetabolismREACTOMER-HSA-210455
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380862192024Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase.0
385796702024Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase.0
380862192024Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase.0
385796702024Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase.0
365873922023Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers.3
366192292023Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway.2
367022512023Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation.1
375314332023PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma.3
379799112023Glutamine synthetase and hepatocellular carcinoma.0
365873922023Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers.3
366192292023Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway.2
367022512023Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation.1
375314332023PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma.3
379799112023Glutamine synthetase and hepatocellular carcinoma.0
362564802022Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1.11

Citation

Dessen P

GLUL (glutamate-ammonia ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45958