CNR1 (cannabinoid receptor 1)

2007-02-01  

Identity

HGNC
CNR1
LOCATION
6q15
LOCUSID
1268
ALIAS
CANN6,CB-R,CB1,CB1A,CB1K5,CB1R,CNR

Other Information

Locus ID:

NCBI: 1268
MIM: 114610
HGNC: 2159
Ensembl: ENSG00000118432

Variants:

dbSNP: 1268
ClinVar: 1268
TCGA: ENSG00000118432
COSMIC: CNR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118432ENST00000362094F8W908
ENSG00000118432ENST00000369499P21554
ENSG00000118432ENST00000369499S5TLS4
ENSG00000118432ENST00000369501P21554
ENSG00000118432ENST00000369501S5TLS4
ENSG00000118432ENST00000428600P21554
ENSG00000118432ENST00000428600S5TLS4
ENSG00000118432ENST00000468898P21554
ENSG00000118432ENST00000468898V5KA96
ENSG00000118432ENST00000549890P21554
ENSG00000118432ENST00000549890S5TLS4
ENSG00000118432ENST00000551417F8W187

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10026aripiprazoleChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA128406954Weight gainDiseaseMultilinkAnnotationassociated24279860
PA153906318Autism Spectrum DisorderDiseaseClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA446878Cocaine-Related DisordersDiseaseClinicalAnnotationassociated
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA449061clozapineChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA449072cocaineChemicalClinicalAnnotationassociated
PA449841haloperidolChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA450688olanzapineChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA451201quetiapineChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA451257risperidoneChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528

References

Pubmed IDYearTitleCitations
359933292024Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.1
381590532024Deciphering the Molecular Association of Human CRIP1a with an Agonist-Bound Cannabinoid Receptor 1.0
383390112024Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells.1
359933292024Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.1
381590532024Deciphering the Molecular Association of Human CRIP1a with an Agonist-Bound Cannabinoid Receptor 1.0
383390112024Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells.1
357925702023The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor.2
362502462023Cannabinoid 1 (CB(1) ) receptor arrestin subtype-selectivity and phosphorylation dependence.4
364405442023Association of CNR1 gene and cannabinoid 1 receptor protein in the human brain.4
366748262023M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter.1
367167712023Regional redistribution of CB1 cannabinoid receptors in human foetal brains with Down's syndrome and their functional modifications in Ts65Dn(+/+) mice.1
368696242023Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis: Role of CB1R-associated proteins and downstream pathways.0
369180372023Lifetime cannabis use and childhood trauma associated with CNR1 genetic variants increase the risk of psychosis: findings from the STREAM study.0
369726482023The association of CNR1 genetic variants with resting-state functional connectivity in youth bipolar disorder.0
376119082023Cannabinoid receptor gene CNR1 is downregulated in subcortical brain samples and upregulated in blood samples of individuals with schizophrenia: A participant data systematic meta-analysis.3

Citation

Dessen P

CNR1 (cannabinoid receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45964