KCNIP3 (potassium voltage-gated channel interacting protein 3)

2007-02-01 Affiliation

Identity

HGNC

KCNIP3

LOCATION

2q11.1

LOCUSID

30818

ALIAS

CSEN,DREAM,KCHIP3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 30818
MIM: 604662
HGNC: 15523
Ensembl: ENSG00000115041

Variants:

dbSNP: 30818
ClinVar: 30818
TCGA: ENSG00000115041
COSMIC: KCNIP3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115041	ENST00000295225	Q9Y2W7
ENSG00000115041	ENST00000295225	A0A024RE22
ENSG00000115041	ENST00000360990	A0A0A0MRH3
ENSG00000115041	ENST00000468529	Q9Y2W7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Muscle contraction	REACTOME	R-HSA-397014
Cardiac conduction	REACTOME	R-HSA-5576891
Phase 1 - inactivation of fast Na+ channels	REACTOME	R-HSA-5576894

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37298129	2023	Emerging Role of DREAM in Healthy Brain and Neurological Diseases.	1
37978395	2023	Loss of p53-DREAM-mediated repression of cell cycle genes as a driver of lymph node metastasis in head and neck cancer.	1
37298129	2023	Emerging Role of DREAM in Healthy Brain and Neurological Diseases.	1
37978395	2023	Loss of p53-DREAM-mediated repression of cell cycle genes as a driver of lymph node metastasis in head and neck cancer.	1
34751735	2022	Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation.	8
35066335	2022	KCNIP3 silence promotes proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma through activating Wnt/β-catenin pathway.	0
34751735	2022	Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation.	8
35066335	2022	KCNIP3 silence promotes proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma through activating Wnt/β-catenin pathway.	0
33626321	2021	PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis.	23
33626321	2021	PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis.	23
32641494	2020	Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3.	3
32641494	2020	Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3.	3
30833638	2019	Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB.	35
30833638	2019	Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB.	35
30272559	2018	KChIP3 coupled to Ca(2+) oscillations exerts a tonic brake on baseline mucin release in the colon.	12

Citation

Dessen P

KCNIP3 (potassium voltage-gated channel interacting protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45968/deep-insight-explorer/deep-insight-explorer/