CXADR (CXADR Ig-like cell adhesion molecule)

2007-02-01  

Identity

HGNC
CXADR
LOCATION
21q21.1
LOCUSID
1525
ALIAS
CAR,CAR4/6,HCAR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1525
MIM: 602621
HGNC: 2559
Ensembl: ENSG00000154639

Variants:

dbSNP: 1525
ClinVar: 1525
TCGA: ENSG00000154639
COSMIC: CXADR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154639ENST00000284878P78310
ENSG00000154639ENST00000356275P78310
ENSG00000154639ENST00000400165P78310
ENSG00000154639ENST00000400166P78310
ENSG00000154639ENST00000400169P78310

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Viral myocarditisKEGGhsa05416
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377594412023CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.1
381466572023CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.0
377594412023CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.1
381466572023CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.0
323348322020Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation.2
328520322020Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques.2
323348322020Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation.2
328520322020Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques.2
303856152019CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer.23
312575152019Differential expression of coxsackievirus and adenovirus receptor in endomyocardial tissue of patients with myocarditis.4
303856152019CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer.23
312575152019Differential expression of coxsackievirus and adenovirus receptor in endomyocardial tissue of patients with myocarditis.4
292694102018Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.6
292694102018Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.6
269405222016Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus Receptor.15

Citation

Dessen P

CXADR (CXADR Ig-like cell adhesion molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45974/img/deep-insight-explorer/case-report-explorer/