Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2356
MIM: 136510
HGNC: 3824
Ensembl: ENSG00000136877
Variants:
dbSNP: 2356
ClinVar: 2356
TCGA: ENSG00000136877
COSMIC: FPGS
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 19902562 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PD | 19902562 | |
| PA451906 | warfarin | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37452621 | 2023 | Effects of single nucleotide polymorphisms of the folylpolyglutamate synthase gene on pemetrexed administration-induced nephropathy. | 0 |
| 37452621 | 2023 | Effects of single nucleotide polymorphisms of the folylpolyglutamate synthase gene on pemetrexed administration-induced nephropathy. | 0 |
| 32940699 | 2021 | Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis. | 8 |
| 34331561 | 2021 | Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon. | 3 |
| 32940699 | 2021 | Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis. | 8 |
| 34331561 | 2021 | Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon. | 3 |
| 32391884 | 2020 | Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia. | 3 |
| 32481505 | 2020 | Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia. | 7 |
| 32694622 | 2020 | FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia. | 6 |
| 32391884 | 2020 | Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia. | 3 |
| 32481505 | 2020 | Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia. | 7 |
| 32694622 | 2020 | FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia. | 6 |
| 30851225 | 2019 | SKA1 induces de novo MTX-resistance in osteosarcoma through inhibiting FPGS transcription. | 5 |
| 30851225 | 2019 | SKA1 induces de novo MTX-resistance in osteosarcoma through inhibiting FPGS transcription. | 5 |
| 30022368 | 2018 | Do SNPs in folate pharmacokinetic pathway alter levels of intracellular methotrexate polyglutamates and affect response? A prospective study in Indian patients. | 2 |
Citation
Dessen P
FPGS (folylpolyglutamate synthase)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45986/fpgs
