NR0B2 (nuclear receptor subfamily 0 group B member 2)

2007-02-01  

Identity

HGNC
NR0B2
LOCATION
1p36.11
LOCUSID
8431
ALIAS
SHP,SHP1

Other Information

Locus ID:

NCBI: 8431
MIM: 604630
HGNC: 7961
Ensembl: ENSG00000131910

Variants:

dbSNP: 8431
ClinVar: 8431
TCGA: ENSG00000131910
COSMIC: NR0B2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131910ENST00000254227Q15466

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

References

Pubmed IDYearTitleCitations
372267372023SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation.1
372267372023SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation.1
351565052022The effectiveness of small heterodimer partner and FGF 19 levels in prediction of perinatal morbidity in intrahepatic cholestasis of pregnancy.0
351565052022The effectiveness of small heterodimer partner and FGF 19 levels in prediction of perinatal morbidity in intrahepatic cholestasis of pregnancy.0
330945102021The orphan nuclear receptor NR0B2 could be a novel susceptibility locus associated with microsatellite-stable, APC mutation-negative early-onset colorectal carcinomas with metabolic manifestation.3
334447832021Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERα via intermolecular interactions.3
337818372021The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease.5
330945102021The orphan nuclear receptor NR0B2 could be a novel susceptibility locus associated with microsatellite-stable, APC mutation-negative early-onset colorectal carcinomas with metabolic manifestation.3
334447832021Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERα via intermolecular interactions.3
337818372021The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease.5
295624942018Aberrant expression of miR-141 and nuclear receptor small heterodimer partner in clinical samples of prostate cancer.8
296661852018Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis.23
299895802018[Suppression of NR0B2 gene in Clear Cell Renal Cell Carcinoma Is Associated with Hypermethylation of Its Promoter].3
295624942018Aberrant expression of miR-141 and nuclear receptor small heterodimer partner in clinical samples of prostate cancer.8
296661852018Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis.23

Citation

Dessen P

NR0B2 (nuclear receptor subfamily 0 group B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45993/cancer-prone-explorer/