Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27232
MIM: 606628
HGNC: 4415
Ensembl: ENSG00000124713
Variants:
dbSNP: 27232
ClinVar: 27232
TCGA: ENSG00000124713
COSMIC: GNMT
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000124713 | ENST00000372808 | Q14749 |
| ENSG00000124713 | ENST00000372808 | V9HW60 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | ClinicalAnnotation | associated | PD | 27452984 | |
| PA450379 | mercaptopurine | Chemical | ClinicalAnnotation | associated | PD | 27452984 | |
| PA450423 | l-methionine | Chemical | Literature, MultilinkAnnotation | associated | 24651765 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36602057 | 2023 | Chemical Biopsy for GNMT as Noninvasive and Tumorigenesis-Relevant Diagnosis of Liver Cancer. | 1 |
| 37047834 | 2023 | Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase. | 0 |
| 38003554 | 2023 | ERVK13-1/miR-873-5p/GNMT Axis Promotes Metastatic Potential in Human Bladder Cancer though Sarcosine Production. | 0 |
| 36602057 | 2023 | Chemical Biopsy for GNMT as Noninvasive and Tumorigenesis-Relevant Diagnosis of Liver Cancer. | 1 |
| 37047834 | 2023 | Folic Acid Ameliorates Renal Injury in Experimental Obstructive Nephropathy: Role of Glycine N-Methyltransferase. | 0 |
| 38003554 | 2023 | ERVK13-1/miR-873-5p/GNMT Axis Promotes Metastatic Potential in Human Bladder Cancer though Sarcosine Production. | 0 |
| 35008908 | 2022 | Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis. | 5 |
| 35008908 | 2022 | Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis. | 5 |
| 33714108 | 2021 | Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis. | 10 |
| 33714108 | 2021 | Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis. | 10 |
| 31057302 | 2019 | Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value. | 52 |
| 31199045 | 2019 | Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression. | 6 |
| 31057302 | 2019 | Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value. | 52 |
| 31199045 | 2019 | Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression. | 6 |
| 30115977 | 2018 | MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma. | 15 |
Citation
Dessen P
GNMT (glycine N-methyltransferase)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45999/gnmt
