ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3)

2007-02-01  

Identity

HGNC
ST3GAL3
LOCATION
1p34.1
LOCUSID
6487
ALIAS
DEE15,EIEE15,MRT12,SIAT6,ST3GALII,ST3Gal
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6487
MIM: 606494
HGNC: 10866
Ensembl: ENSG00000126091

Variants:

dbSNP: 6487
ClinVar: 6487
TCGA: ENSG00000126091
COSMIC: ST3GAL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126091ENST00000262915Q11203
ENSG00000126091ENST00000330208Q11203
ENSG00000126091ENST00000332628A0A2U3TZH9
ENSG00000126091ENST00000335430Q11203
ENSG00000126091ENST00000347631Q11203
ENSG00000126091ENST00000351035Q11203
ENSG00000126091ENST00000353126Q11203
ENSG00000126091ENST00000361392Q11203
ENSG00000126091ENST00000361400Q11203
ENSG00000126091ENST00000361746A0A2U3TZK9
ENSG00000126091ENST00000361812Q11203
ENSG00000126091ENST00000372362Q11203
ENSG00000126091ENST00000372365Q11203
ENSG00000126091ENST00000372366Q11203
ENSG00000126091ENST00000372367Q11203
ENSG00000126091ENST00000372368A0A2U3TZM2
ENSG00000126091ENST00000372369Q11203
ENSG00000126091ENST00000372372Q11203
ENSG00000126091ENST00000372374Q11203
ENSG00000126091ENST00000461066E9PJX2
ENSG00000126091ENST00000469715Q11203
ENSG00000126091ENST00000479383E9PJI3
ENSG00000126091ENST00000484868A0A2R8Y7D5
ENSG00000126091ENST00000489897Q11203
ENSG00000126091ENST00000490502H0YEP7
ENSG00000126091ENST00000490541Q11203
ENSG00000126091ENST00000528371Q11203
ENSG00000126091ENST00000530154E9PNN5
ENSG00000126091ENST00000530581Q11203
ENSG00000126091ENST00000531451Q11203
ENSG00000126091ENST00000531816Q11203
ENSG00000126091ENST00000531993Q11203
ENSG00000126091ENST00000532911E9PJI3
ENSG00000126091ENST00000533212Q11203
ENSG00000126091ENST00000533933A0A2U3U052
ENSG00000126091ENST00000533997Q11203
ENSG00000126091ENST00000545417Q11203
ENSG00000126091ENST00000642194A0A2R8YDA9
ENSG00000126091ENST00000642331A0A2R8YDJ6
ENSG00000126091ENST00000642504Q11203
ENSG00000126091ENST00000642780A0A2R8YCV7
ENSG00000126091ENST00000642934Q11203
ENSG00000126091ENST00000642949Q11203
ENSG00000126091ENST00000643252A0A2R8Y6H4
ENSG00000126091ENST00000643283A0A2R8YF05
ENSG00000126091ENST00000643597A0A2R8Y7B2
ENSG00000126091ENST00000643813A0A2R8Y847
ENSG00000126091ENST00000643886A0A2R8YFP6
ENSG00000126091ENST00000643989A0A2R8YH87
ENSG00000126091ENST00000644195Q11203
ENSG00000126091ENST00000644287A0A2R8Y7J2
ENSG00000126091ENST00000644645A0A2R8Y717
ENSG00000126091ENST00000644922A0A2R8YFA0
ENSG00000126091ENST00000645034A0A2R8Y7Z2
ENSG00000126091ENST00000645117A0A2R8YE42
ENSG00000126091ENST00000645142Q11203
ENSG00000126091ENST00000645161A0A2R8Y682
ENSG00000126091ENST00000645165Q11203
ENSG00000126091ENST00000645394A0A2R8Y6K5
ENSG00000126091ENST00000645640Q11203
ENSG00000126091ENST00000645705A0A2R8YFI8
ENSG00000126091ENST00000646027A0A2R8YDB0
ENSG00000126091ENST00000646032A0A2R8Y7H6
ENSG00000126091ENST00000646069A0A2R8YFM5
ENSG00000126091ENST00000646096E9PJI3
ENSG00000126091ENST00000646109A0A2R8Y244
ENSG00000126091ENST00000646686A0A2R8Y732
ENSG00000126091ENST00000646971Q11203
ENSG00000126091ENST00000647128A0A2R8Y4Y4
ENSG00000126091ENST00000647134A0A2R8Y6U8
ENSG00000126091ENST00000647148A0A2R8Y7D8
ENSG00000126091ENST00000647237A0A2R8Y6L4
ENSG00000126091ENST00000647482A0A2R8Y6U3
ENSG00000126091ENST00000647503A0A2R8Y4W6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Other types of O-glycan biosynthesisKEGGko00514
Glycosaminoglycan biosynthesis - keratan sulfateKEGGko00533
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Other types of O-glycan biosynthesisKEGGhsa00514
Glycosaminoglycan biosynthesis - keratan sulfateKEGGhsa00533
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854
Mannose type O-glycan biosynthesisKEGGko00515
Mannose type O-glycan biosynthesisKEGGhsa00515

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386020292024Human ST3Gal II and ST6GalNAc IV genes increase human serum-mediated cytotoxicity to xenogeneic cells.0
386020292024Human ST3Gal II and ST6GalNAc IV genes increase human serum-mediated cytotoxicity to xenogeneic cells.0
370670652023The epilepsy phenotype of ST3GAL3-related developmental and epileptic encephalopathy.2
370670652023The epilepsy phenotype of ST3GAL3-related developmental and epileptic encephalopathy.2
364059922022ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway.0
364059922022ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway.0
315840662020A novel nonsense and inactivating variant of ST3GAL3 in two infant siblings suffering severe epilepsy and expressing circulating CA19.9.14
319146692020ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.29
320465342020Contribution of Intellectual Disability-Related Genes to ADHD Risk and to Locomotor Activity in Drosophila.13
326665832020A novel variant of ST3GAL3 causes non-syndromic autosomal recessive intellectual disability in Iranian patients.3
315840662020A novel nonsense and inactivating variant of ST3GAL3 in two infant siblings suffering severe epilepsy and expressing circulating CA19.9.14
319146692020ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.29
320465342020Contribution of Intellectual Disability-Related Genes to ADHD Risk and to Locomotor Activity in Drosophila.13
326665832020A novel variant of ST3GAL3 causes non-syndromic autosomal recessive intellectual disability in Iranian patients.3
317020362019ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling.10

Citation

Dessen P

ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46012/img/js/lib/cancer-prone-explorer/