RFX1 (regulatory factor X1)

2007-02-01 Affiliation

Identity

HGNC

RFX1

LOCATION

19p13.12

LOCUSID

5989

ALIAS

EFC,RFX

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5989
MIM: 600006
HGNC: 9982
Ensembl: ENSG00000132005

Variants:

dbSNP: 5989
ClinVar: 5989
TCGA: ENSG00000132005
COSMIC: RFX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132005	ENST00000254325	P22670
ENSG00000132005	ENST00000588885	K7EIZ8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37301270	2023	RXR agonist, Bexarotene, effectively reduces drug resistance via regulation of RFX1 in embryonic carcinoma cells.	2
37301270	2023	RXR agonist, Bexarotene, effectively reduces drug resistance via regulation of RFX1 in embryonic carcinoma cells.	2
35143476	2022	RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells.	3
35143476	2022	RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells.	3
33655492	2021	RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions.	6
33655492	2021	RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions.	6
30654936	2019	Recruitment of the protein phosphatase-1 catalytic subunit to promoters by the dual-function transcription factor RFX1.	4
30857550	2019	RFX1 downregulation contributes to TLR4 overexpression in CD14(+) monocytes via epigenetic mechanisms in coronary artery disease.	11
30654936	2019	Recruitment of the protein phosphatase-1 catalytic subunit to promoters by the dual-function transcription factor RFX1.	4
30857550	2019	RFX1 downregulation contributes to TLR4 overexpression in CD14(+) monocytes via epigenetic mechanisms in coronary artery disease.	11
29317724	2018	RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.	5
29422534	2018	IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.	49
29764705	2018	Downregulation of RFX1 predicts poor prognosis of patients with small hepatocellular carcinoma.	7
29317724	2018	RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.	5
29422534	2018	IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.	49

Citation

Dessen P

RFX1 (regulatory factor X1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46019/teaching-explorer/css/lib/cancer-prone-explorer/