PRICKLE1 (prickle planar cell polarity protein 1)

2007-02-01  

Identity

HGNC
LOCATION
12q12
LOCUSID
ALIAS
EPM1B,RILP
FUSION GENES

Other Information

Locus ID:

NCBI: 144165
MIM: 608500
HGNC: 17019
Ensembl: ENSG00000139174

Variants:

dbSNP: 144165
ClinVar: 144165
TCGA: ENSG00000139174
COSMIC: PRICKLE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139174ENST00000345127Q96MT3
ENSG00000139174ENST00000345127A0A024R0W7
ENSG00000139174ENST00000445766Q96MT3
ENSG00000139174ENST00000445766A0A024R0W7
ENSG00000139174ENST00000455697Q96MT3
ENSG00000139174ENST00000455697A0A024R0W7
ENSG00000139174ENST00000547113F8W1Q8
ENSG00000139174ENST00000548696Q96MT3
ENSG00000139174ENST00000548696A0A024R0W7
ENSG00000139174ENST00000551050F8W1J1
ENSG00000139174ENST00000552108F8VUG8
ENSG00000139174ENST00000552240Q96MT3
ENSG00000139174ENST00000552240A0A024R0W7
ENSG00000139174ENST00000639566Q96MT3
ENSG00000139174ENST00000639566A0A024R0W7
ENSG00000139174ENST00000639589Q96MT3
ENSG00000139174ENST00000639589A0A024R0W7
ENSG00000139174ENST00000639958Q96MT3
ENSG00000139174ENST00000639958A0A024R0W7
ENSG00000139174ENST00000640055Q96MT3
ENSG00000139174ENST00000640055A0A024R0W7
ENSG00000139174ENST00000640132Q96MT3
ENSG00000139174ENST00000640132A0A024R0W7
ENSG00000139174ENST00000640646F8W1Q8
ENSG00000139174ENST00000640801A0A1W2PPC7

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
340011342021PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia.12
340011342021PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia.12
305649772019Sudden unexpected death with rare compound heterozygous variants in PRICKLE1.2
309717752019ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer.9
305649772019Sudden unexpected death with rare compound heterozygous variants in PRICKLE1.2
309717752019ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer.9
303457272018PRICKLE1-related early onset epileptic encephalopathy.6
303457272018PRICKLE1-related early onset epileptic encephalopathy.6
270363982016Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma.15
271847342016PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2.42
273781692016Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.23
270363982016Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma.15
271847342016PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2.42
273781692016Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.23
243124982013PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.28

Citation

Dessen P

PRICKLE1 (prickle planar cell polarity protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46033/img/case-report-explorer/css/lib/bootstrap.min.css