HAGH (hydroxyacylglutathione hydrolase)

2007-02-01 Affiliation

Identity

HGNC

HAGH

LOCATION

16p13.3

LOCUSID

3029

ALIAS

GLO2,GLX2,GLXII,HAGH1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3029
MIM: 138760
HGNC: 4805
Ensembl: ENSG00000063854

Variants:

dbSNP: 3029
ClinVar: 3029
TCGA: ENSG00000063854
COSMIC: HAGH

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000063854	ENST00000397353	Q16775
ENSG00000063854	ENST00000397356	Q16775
ENSG00000063854	ENST00000455446	Q16775
ENSG00000063854	ENST00000564445	H3BPK3
ENSG00000063854	ENST00000566644	H3BV79
ENSG00000063854	ENST00000566709	H3BPQ4
ENSG00000063854	ENST00000569339	H3BQW8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pyruvate metabolism	KEGG	ko00620
Pyruvate metabolism	KEGG	hsa00620
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycle	REACTOME	R-HSA-71406
Pyruvate metabolism	REACTOME	R-HSA-70268

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33725370	2021	Sirtuin 2 Regulates Protein LactoylLys Modifications.	14
33725370	2021	Sirtuin 2 Regulates Protein LactoylLys Modifications.	14
32427856	2020	CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers.	11
32427856	2020	CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers.	11
29385039	2018	Glyoxalases in Urological Malignancies.	39
29950256	2018	Gene Expression of Glyoxalase II in Diabetic Retinopathy.	2
29385039	2018	Glyoxalases in Urological Malignancies.	39
29950256	2018	Gene Expression of Glyoxalase II in Diabetic Retinopathy.	2
27696457	2017	Glyoxalase 2 Is Involved in Human Prostate Cancer Progression as Part of a Mechanism Driven By PTEN/PI3K/AKT/mTOR Signaling With Involvement of PKM2 and ERα.	35
27696457	2017	Glyoxalase 2 Is Involved in Human Prostate Cancer Progression as Part of a Mechanism Driven By PTEN/PI3K/AKT/mTOR Signaling With Involvement of PKM2 and ERα.	35
26914966	2016	The glyoxalase enzymes are differentially localized in epidermis and regulated during ageing and photoageing.	8
27935136	2016	A possible S-glutathionylation of specific proteins by glyoxalase II: An in vitro and in silico study.	16
26914966	2016	The glyoxalase enzymes are differentially localized in epidermis and regulated during ageing and photoageing.	8
27935136	2016	A possible S-glutathionylation of specific proteins by glyoxalase II: An in vitro and in silico study.	16
24671236	2015	Weak association of glyoxalase 1 (GLO1) variants with autism spectrum disorder.	9

Citation

Dessen P

HAGH (hydroxyacylglutathione hydrolase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46037