ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)

2007-02-01  

Identity

HGNC
ZDHHC17
LOCATION
12q21.2
LOCUSID
23390
ALIAS
DHHC-17,DHHC17,HIP14,HIP3,HSPC294,HYPH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23390
MIM: 607799
HGNC: 18412
Ensembl: ENSG00000186908

Variants:

dbSNP: 23390
ClinVar: 23390
TCGA: ENSG00000186908
COSMIC: ZDHHC17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186908ENST00000426126Q8IUH5
ENSG00000186908ENST00000546778F8VUG7
ENSG00000186908ENST00000547604H0YIN1
ENSG00000186908ENST00000547620H0YHF0
ENSG00000186908ENST00000549682F8VPW2
ENSG00000186908ENST00000549944H0YI74
ENSG00000186908ENST00000550163H0YIP7
ENSG00000186908ENST00000550876F8VX48
ENSG00000186908ENST00000551407H0YHW0
ENSG00000186908ENST00000552453H0YIK0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
319380472020Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression.32
319380472020Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression.32
287571452017Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.34
288828952017Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.17
287571452017Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.34
288828952017Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.17
258499182015Aberrant palmitoylation in Huntington disease.16
276116752015Chlamydia pneumoniae CPj0783 interaction with Huntingtin-protein14.2
258499182015Aberrant palmitoylation in Huntington disease.16
276116752015Chlamydia pneumoniae CPj0783 interaction with Huntingtin-protein14.2
246513842014Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L.12
247053542014The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.33
246513842014Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L.12
247053542014The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.33
240017712013DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane.20

Citation

Dessen P

ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46045/css/teaching-explorer/