Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 259
MIM: 176870
HGNC: 453
Ensembl: ENSG00000106927
Variants:
dbSNP: 259
ClinVar: 259
TCGA: ENSG00000106927
COSMIC: AMBP
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000106927 | ENST00000265132 | P02760 |
| ENSG00000106927 | ENST00000466610 | S4R471 |
| ENSG00000106927 | ENST00000603230 | S4R3Y4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Vesicle-mediated transport | REACTOME | R-HSA-5653656 |
| Binding and Uptake of Ligands by Scavenger Receptors | REACTOME | R-HSA-2173782 |
| Scavenging of heme from plasma | REACTOME | R-HSA-2168880 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37861555 | 2023 | Correlation between peripheral blood α1-MG, DNMT1 expression, and the severity of diabetic nephropathy renal pathological damage. | 0 |
| 37861555 | 2023 | Correlation between peripheral blood α1-MG, DNMT1 expression, and the severity of diabetic nephropathy renal pathological damage. | 0 |
| 32092412 | 2021 | Human radical scavenger α(1)-microglobulin protects against hemolysis in vitro and α(1)-microglobulin knockout mice exhibit a macrocytic anemia phenotype. | 14 |
| 33607500 | 2021 | Binding of the human antioxidation protein α(1)-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro. | 2 |
| 34206377 | 2021 | Ferryl Hemoglobin and Heme Induce A(1)-Microglobulin in Hemorrhaged Atherosclerotic Lesions with Inhibitory Function against Hemoglobin and Lipid Oxidation. | 4 |
| 32092412 | 2021 | Human radical scavenger α(1)-microglobulin protects against hemolysis in vitro and α(1)-microglobulin knockout mice exhibit a macrocytic anemia phenotype. | 14 |
| 33607500 | 2021 | Binding of the human antioxidation protein α(1)-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro. | 2 |
| 34206377 | 2021 | Ferryl Hemoglobin and Heme Induce A(1)-Microglobulin in Hemorrhaged Atherosclerotic Lesions with Inhibitory Function against Hemoglobin and Lipid Oxidation. | 4 |
| 32915914 | 2020 | Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction. | 6 |
| 33008134 | 2020 | The Role of α(1)-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions. | 16 |
| 32915914 | 2020 | Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction. | 6 |
| 33008134 | 2020 | The Role of α(1)-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions. | 16 |
| 31189914 | 2019 | Alpha-1 microglobulin as a potential therapeutic candidate for treatment of hypertension and oxidative stress in the STOX1 preeclampsia mouse model. | 17 |
| 31233368 | 2019 | The Effect of AMBP SNPs, Their Haplotypes, and Gene-Environment Interactions on the Risk of Atherothrombotic Stroke Among the Chinese Population. | 1 |
| 31281843 | 2019 | The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus. | 4 |
Citation
Dessen P
AMBP (alpha-1-microglobulin/bikunin precursor)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46052/ambp
