PENK (proenkephalin)

2007-02-01  

Identity

HGNC
PENK
LOCATION
8q12.1
LOCUSID
5179
ALIAS
PE,PENK-A

Other Information

Locus ID:

NCBI: 5179
MIM: 131330
HGNC: 8831
Ensembl: ENSG00000181195

Variants:

dbSNP: 5179
ClinVar: 5179
TCGA: ENSG00000181195
COSMIC: PENK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181195ENST00000314922P01210
ENSG00000181195ENST00000314922A0A024R7V4
ENSG00000181195ENST00000451791P01210
ENSG00000181195ENST00000451791A0A024R7V4
ENSG00000181195ENST00000517415H0YBT5
ENSG00000181195ENST00000518770E5RJ72
ENSG00000181195ENST00000518974E5RFR1
ENSG00000181195ENST00000523051E5RIP6

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382004542024Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.0
382004542024Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.0
380579042023Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis.4
380579042023Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis.4
319735682020Proenkephalin A Adds No Incremental Prognostic Value After Acute Ischemic Stroke.2
323346332020PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway.5
319735682020Proenkephalin A Adds No Incremental Prognostic Value After Acute Ischemic Stroke.2
323346332020PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway.5
310919932019Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure.17
310919932019Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure.17
290302292018Elevation of Proenkephalin 143-183 in Cerebrospinal Fluid in Moyamoya Disease.2
294668912018Proenkephalin and risk of developing chronic kidney disease: the Prevention of Renal and Vascular End-stage Disease study.6
296732322018Proinflammatory Markers, Chemokines, and Enkephalin in Patients Suffering from Dry Eye Disease.29
290302292018Elevation of Proenkephalin 143-183 in Cerebrospinal Fluid in Moyamoya Disease.2
294668912018Proenkephalin and risk of developing chronic kidney disease: the Prevention of Renal and Vascular End-stage Disease study.6

Citation

Dessen P

PENK (proenkephalin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46058/js/lib/js/lib/zoomerang.js