Identity
HGNC
LOCATION
2q35
LOCUSID
ALIAS
BG37,GPCR19,GPR131,M-BAR,TGR5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 151306
MIM: 610147
HGNC: 19680
Ensembl: ENSG00000179921
Variants:
dbSNP: 151306
ClinVar: 151306
TCGA: ENSG00000179921
COSMIC: GPBAR1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000179921 | ENST00000479077 | Q8TDU6 |
| ENSG00000179921 | ENST00000519574 | Q8TDU6 |
| ENSG00000179921 | ENST00000521462 | Q8TDU6 |
| ENSG00000179921 | ENST00000522678 | Q8TDU6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37989444 | 2024 | Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO. | 1 |
| 38329942 | 2024 | The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome. | 1 |
| 38806072 | 2024 | Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute cholestatic liver injury via antagonizing NLRP3-ASC inflammasome. | 0 |
| 38941459 | 2024 | TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing. | 0 |
| 37989444 | 2024 | Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO. | 1 |
| 38329942 | 2024 | The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome. | 1 |
| 38806072 | 2024 | Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute cholestatic liver injury via antagonizing NLRP3-ASC inflammasome. | 0 |
| 38941459 | 2024 | TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing. | 0 |
| 37926268 | 2023 | Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease. | 0 |
| 37926268 | 2023 | Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease. | 0 |
| 34904217 | 2022 | GPBAR1 promotes proliferation and is related to poor prognosis of high-grade glioma via inducing MAFB expression. | 0 |
| 35406751 | 2022 | GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation. | 4 |
| 35464490 | 2022 | GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease. | 6 |
| 35858343 | 2022 | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. | 6 |
| 35864954 | 2022 | Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling. | 7 |
Citation
Dessen P
GPBAR1 (G protein-coupled bile acid receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46065/gpbar1
