CD46 (CD46 molecule)

2007-02-01  

Identity

HGNC
CD46
LOCATION
1q32.2
LOCUSID
4179
ALIAS
AHUS2,MCP,MIC10,TLX,TRA2.10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4179
MIM: 120920
HGNC: 6953
Ensembl: ENSG00000117335

Variants:

dbSNP: 4179
ClinVar: 4179
TCGA: ENSG00000117335
COSMIC: CD46

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117335ENST00000322875P15529
ENSG00000117335ENST00000322918P15529
ENSG00000117335ENST00000354848P15529
ENSG00000117335ENST00000357714P15529
ENSG00000117335ENST00000358170P15529
ENSG00000117335ENST00000360212P15529
ENSG00000117335ENST00000367041P15529
ENSG00000117335ENST00000367042P15529
ENSG00000117335ENST00000367047P15529
ENSG00000117335ENST00000462968R4GN18
ENSG00000117335ENST00000480003P15529

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375799822024The association between CD46 expression in B cells and the pathogenesis of airway allergy.0
375799822024The association between CD46 expression in B cells and the pathogenesis of airway allergy.0
374777602023Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation.1
376683492023The CD46 ectodomain participates in human cytomegalovirus infection of epithelial cells.1
379214712023Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.0
381405382023Computational Analysis of CD46 Protein Interaction with SARS-CoV-2 Structural Proteins: Elucidating a Putative Viral Entry Mechanism into Human Cells.0
374777602023Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation.1
376683492023The CD46 ectodomain participates in human cytomegalovirus infection of epithelial cells.1
379214712023Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.0
381405382023Computational Analysis of CD46 Protein Interaction with SARS-CoV-2 Structural Proteins: Elucidating a Putative Viral Entry Mechanism into Human Cells.0
347874572022Ex Vivo and In Vivo CD46 Receptor Utilization by Species D Human Adenovirus Serotype 26 (HAdV26).7
350197172022CD46 Isoforms Influence the Mode of Entry by Human Herpesvirus 6A/B in T Cells.1
362107072022[Silencing CD46 and DSG2 in host A549 cells inhibits entry of human adenovirus type 3 and type 7 and reduces interleukin-8 release].0
362113942022Genetic analysis of CFH and MCP in Egyptian patients with immune-complex proliferative glomerulonephritis.1
365752332022CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity.4

Citation

Dessen P

CD46 (CD46 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46109/deep-insight-explorer/js/favicon/manifest.json