Identity
HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
EIT-6,EIT6,HIF-PH1,HIFPH1,HPH-1,HPH-3,PHD1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 112398
MIM: 606424
HGNC: 14660
Ensembl: ENSG00000269858
Variants:
dbSNP: 112398
ClinVar: 112398
TCGA: ENSG00000269858
COSMIC: EGLN2
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38360997 | 2024 | VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation. | 1 |
| 38360997 | 2024 | VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation. | 1 |
| 37847687 | 2023 | Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension. | 1 |
| 37847687 | 2023 | Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension. | 1 |
| 32458625 | 2020 | Association of EGLN2 rs10680577 Polymorphism with the Risk and Clinicopathological Features of Patients with Prostate Cancer. | 0 |
| 32458625 | 2020 | Association of EGLN2 rs10680577 Polymorphism with the Risk and Clinicopathological Features of Patients with Prostate Cancer. | 0 |
| 30665327 | 2019 | EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC. | 20 |
| 31414584 | 2019 | Association between an indel polymorphism within the distal promoter of EGLN2 and cancer risk: An updated meta-analysis. | 1 |
| 31500697 | 2019 | Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. | 52 |
| 31729379 | 2019 | Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer. | 18 |
| 30665327 | 2019 | EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC. | 20 |
| 31414584 | 2019 | Association between an indel polymorphism within the distal promoter of EGLN2 and cancer risk: An updated meta-analysis. | 1 |
| 31500697 | 2019 | Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. | 52 |
| 31729379 | 2019 | Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer. | 18 |
| 29277791 | 2018 | Strong Prolyl Hydroxylase Domain 1 Expression Predicts Poor Outcome in Radiotherapy-treated Patients with Classical Hodgkin's Lymphoma. | 3 |
Citation
Dessen P
EGLN2 (egl-9 family hypoxia inducible factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46124/egln2
