LYZ (lysozyme)

2007-02-01  

Identity

HGNC
LYZ
LOCATION
12q15
LOCUSID
4069
ALIAS
LYZF1,LZM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4069
MIM: 153450
HGNC: 6740
Ensembl: ENSG00000090382

Variants:

dbSNP: 4069
ClinVar: 4069
TCGA: ENSG00000090382
COSMIC: LYZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090382ENST00000261267P61626
ENSG00000090382ENST00000261267B2R4C5
ENSG00000090382ENST00000548839F8VV32
ENSG00000090382ENST00000549690A0A0B4J259

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000
9000
10000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374026492023Length and saturation of fatty acids in phosphatidylserine determine the rate of lysozyme aggregation simultaneously altering the structure and toxicity of amyloid oligomers and fibrils.3
374026492023Length and saturation of fatty acids in phosphatidylserine determine the rate of lysozyme aggregation simultaneously altering the structure and toxicity of amyloid oligomers and fibrils.3
336407962021Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme.1
336407962021Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme.1
319781142020Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme.1
325225532020Analyses of displacements resulting from a point mutation in proteins.1
319781142020Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme.1
325225532020Analyses of displacements resulting from a point mutation in proteins.1
313913202019Lysozyme elicits pain during nerve injury by neuronal Toll-like receptor 4 activation and has therapeutic potential in neuropathic pain.12
316941632019Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage.15
313913202019Lysozyme elicits pain during nerve injury by neuronal Toll-like receptor 4 activation and has therapeutic potential in neuropathic pain.12
316941632019Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage.15
294461502018Antimicrobial peptide gene expression in periodontitis patients: A pilot study.6
294461502018Antimicrobial peptide gene expression in periodontitis patients: A pilot study.6
278258042017A comparative study of fibrillation kinetics of two homologous proteins under identical solution condition.7

Citation

Dessen P

LYZ (lysozyme)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46133