PPIA (peptidylprolyl isomerase A)

2007-02-01  

Identity

HGNC
PPIA
LOCATION
7p13
LOCUSID
5478
ALIAS
CYPA,CYPH,HEL-S-69p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5478
MIM: 123840
HGNC: 9253
Ensembl: ENSG00000196262

Variants:

dbSNP: 5478
ClinVar: 5478
TCGA: ENSG00000196262
COSMIC: PPIA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196262ENST00000355968P62937
ENSG00000196262ENST00000415933F8WE65
ENSG00000196262ENST00000451562C9J5S7
ENSG00000196262ENST00000468812P62937
ENSG00000196262ENST00000468812V9HWF5
ENSG00000196262ENST00000479021E5RIZ5
ENSG00000196262ENST00000489459P62937
ENSG00000196262ENST00000620047P62937

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Early Phase of HIV Life CycleREACTOMER-HSA-162594
Binding and entry of HIV virionREACTOMER-HSA-173107
Uncoating of the HIV VirionREACTOMER-HSA-162585
Reverse Transcription of HIV RNAREACTOMER-HSA-162589
Minus-strand DNA synthesisREACTOMER-HSA-164516
Plus-strand DNA synthesisREACTOMER-HSA-164525
Integration of provirusREACTOMER-HSA-162592
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Assembly Of The HIV VirionREACTOMER-HSA-175474
Budding and maturation of HIV virionREACTOMER-HSA-162588
Host Interactions of HIV factorsREACTOMER-HSA-162909
APOBEC3G mediated resistance to HIV-1 infectionREACTOMER-HSA-180689
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388308682024PPIA dictates NRF2 stability to promote lung cancer progression.0
388308682024PPIA dictates NRF2 stability to promote lung cancer progression.0
365356292023Cyclophilin A accelerates SiO(2)-induced macrophage foaming.1
371294152023A Tripartite Complex HIV-1 Tat-Cyclophilin A-Capsid Protein Enables Tat Encapsidation That Is Required for HIV-1 Infectivity.2
375588762023TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6.8
377619062023New Insights into Dyskerin-CypA Interaction: Implications for X-Linked Dyskeratosis Congenita and Beyond.0
378433712023Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.3
379267572023Bioinformatics analysis and experimental validation of tumorigenic role of PPIA in gastric cancer.1
379930812023Secreted cyclophilin A is non-genotoxic but acts as a tumor promoter.0
365356292023Cyclophilin A accelerates SiO(2)-induced macrophage foaming.1
371294152023A Tripartite Complex HIV-1 Tat-Cyclophilin A-Capsid Protein Enables Tat Encapsidation That Is Required for HIV-1 Infectivity.2
375588762023TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6.8
377619062023New Insights into Dyskerin-CypA Interaction: Implications for X-Linked Dyskeratosis Congenita and Beyond.0
378433712023Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.3
379267572023Bioinformatics analysis and experimental validation of tumorigenic role of PPIA in gastric cancer.1

Citation

Dessen P

PPIA (peptidylprolyl isomerase A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46137