DUOX2 (dual oxidase 2)

2007-02-01  

Identity

HGNC
DUOX2
LOCATION
15q21.1
LOCUSID
50506
ALIAS
LNOX2,NOXEF2,P138-TOX,TDH6,THOX2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 50506
MIM: 606759
HGNC: 13273
Ensembl: ENSG00000140279

Variants:

dbSNP: 50506
ClinVar: 50506
TCGA: ENSG00000140279
COSMIC: DUOX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140279ENST00000389039X6RAN8
ENSG00000140279ENST00000603300Q9NRD8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Thyroxine biosynthesisREACTOMER-HSA-209968

References

Pubmed IDYearTitleCitations
366076422023DUOX2 regulates secreted factors in virus-infected respiratory epithelial cells that contribute to neutrophil attraction and activation.1
375178012023Another Breach in the Wall: Impaired Epithelial DUOX2 Activity Fuels Metabolic Syndrome.0
366076422023DUOX2 regulates secreted factors in virus-infected respiratory epithelial cells that contribute to neutrophil attraction and activation.1
375178012023Another Breach in the Wall: Impaired Epithelial DUOX2 Activity Fuels Metabolic Syndrome.0
355070002022Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.2
359600912022Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.4
355070002022Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.2
359600912022Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.4
325310522021DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.18
328036772021Identification and analyzes of DUOX2 mutations in two familial congenital hypothyroidism cases.1
336285962021A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis.4
336310112021Dual Oxidase System Genes Defects in Children With Congenital Hypothyroidism.4
336517152021DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.24
337482702021DUOX2 As a Potential Prognostic Marker which Promotes Cell Motility and Proliferation in Pancreatic Cancer.3
345648492021Correlation of DUOX2 residual enzymatic activity with phenotype in congenital hypothyroidism caused by biallelic DUOX2 defects.2

Citation

Dessen P

DUOX2 (dual oxidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46154/js/lib/gene-fusions-explorer/css/template-card.css