CCR5 (C-C motif chemokine receptor 5)

2007-02-01  

Identity

HGNC
CCR5
LOCATION
3p21.31
LOCUSID
1234
ALIAS
CC-CKR-5,CCCKR5,CCR-5,CD195,CKR-5,CKR5,CMKBR5,IDDM22

Other Information

Locus ID:

NCBI: 1234
MIM: 601373
HGNC: 1606
Ensembl: ENSG00000160791

Variants:

dbSNP: 1234
ClinVar: 1234
TCGA: ENSG00000160791
COSMIC: CCR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160791ENST00000292303P51681
ENSG00000160791ENST00000292303Q38L21
ENSG00000160791ENST00000445772P51681
ENSG00000160791ENST00000445772Q38L21

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Early Phase of HIV Life CycleREACTOMER-HSA-162594
Binding and entry of HIV virionREACTOMER-HSA-173107
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Interleukin-10 signalingREACTOMER-HSA-6783783

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164768835maravirocChemicalLabelAnnotationassociated

References

Pubmed IDYearTitleCitations
374897642024CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia.2
378667192024The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling.2
379622802024CCR5 promoter polymorphisms associated with nonsmall cell lung cancer.0
379844132024CCR5 promoter region polymorphisms in systemic lupus erythematosus.0
381676362024Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions.0
383292282024Higher CCR5 density on CD4 + T-cells in mothers and infants is associated with increased risk of in-utero HIV-1 transmission.0
385075002024JAK/STAT signaling pathway affects CCR5 expression in human CD4(+) T cells.1
387195432024CCR5 and CCL5 in metastatic colorectal cancer.0
387708252024The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and boosts HIV-1 R5 replication.0
374897642024CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia.2
378667192024The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling.2
379622802024CCR5 promoter polymorphisms associated with nonsmall cell lung cancer.0
379844132024CCR5 promoter region polymorphisms in systemic lupus erythematosus.0
381676362024Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions.0
383292282024Higher CCR5 density on CD4 + T-cells in mothers and infants is associated with increased risk of in-utero HIV-1 transmission.0

Citation

Dessen P

CCR5 (C-C motif chemokine receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46155