Identity
HGNC
LOCATION
2q14.3
LOCUSID
ALIAS
LGMD2W,MDRCMTT,PINCH-2,PINCH2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55679
MIM: 607908
HGNC: 16084
Ensembl: ENSG00000072163
Variants:
dbSNP: 55679
ClinVar: 55679
TCGA: ENSG00000072163
COSMIC: LIMS2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell-Cell communication | REACTOME | R-HSA-1500931 |
| Cell junction organization | REACTOME | R-HSA-446728 |
| Cell-extracellular matrix interactions | REACTOME | R-HSA-446353 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32752897 | 2020 | Fluid shear stress modulates endothelial inflammation by targeting LIMS2. | 5 |
| 32752897 | 2020 | Fluid shear stress modulates endothelial inflammation by targeting LIMS2. | 5 |
| 27590440 | 2016 | Signaling via PINCH: Functions, binding partners and implications in human diseases. | 15 |
| 27590440 | 2016 | Signaling via PINCH: Functions, binding partners and implications in human diseases. | 15 |
| 25346044 | 2015 | PINCH-2 presents functional copy number variation and suppresses migration of colon cancer cells by paracrine activity. | 7 |
| 25589244 | 2015 | LIMS2 mutations are associated with a novel muscular dystrophy, severe cardiomyopathy and triangular tongues. | 9 |
| 25346044 | 2015 | PINCH-2 presents functional copy number variation and suppresses migration of colon cancer cells by paracrine activity. | 7 |
| 25589244 | 2015 | LIMS2 mutations are associated with a novel muscular dystrophy, severe cardiomyopathy and triangular tongues. | 9 |
| 20500520 | 2011 | PINCH-2 expression in cancers involving serosal effusions using quantitative PCR. | 2 |
| 20500520 | 2011 | PINCH-2 expression in cancers involving serosal effusions using quantitative PCR. | 2 |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. | 37 |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. | 37 |
| 16959213 | 2006 | The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration. | 24 |
| 16959213 | 2006 | The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration. | 24 |
| 12167643 | 2002 | Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. | 43 |
Citation
Dessen P
LIMS2 (LIM zinc finger domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46170/lims2
