CRISP3 (cysteine rich secretory protein 3)

2007-02-01  

Identity

HGNC
CRISP3
LOCATION
6p12.3
LOCUSID
10321
ALIAS
Aeg2,CRISP-3,CRS3,SGP28,dJ442L6.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10321
MIM: 618062
HGNC: 16904
Ensembl: ENSG00000096006

Variants:

dbSNP: 10321
ClinVar: 10321
TCGA: ENSG00000096006
COSMIC: CRISP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000096006ENST00000263045P54108
ENSG00000096006ENST00000354620I3L0A1
ENSG00000096006ENST00000371159J3KPA1
ENSG00000096006ENST00000433368P54108

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
303540342019Cysteine-rich secretory protein 3: inflammation role in adult varicocoele.5
306090352019Low expression of CRISP3 predicts a favorable prognosis in patients with mammary carcinoma.10
303540342019Cysteine-rich secretory protein 3: inflammation role in adult varicocoele.5
306090352019Low expression of CRISP3 predicts a favorable prognosis in patients with mammary carcinoma.10
263695302016Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.5
263695302016Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.5
257157942015Endometrial CRISP3 is regulated throughout the mouse estrous and human menstrual cycle and facilitates adhesion and proliferation of endometrial epithelial cells.9
257157942015Endometrial CRISP3 is regulated throughout the mouse estrous and human menstrual cycle and facilitates adhesion and proliferation of endometrial epithelial cells.9
249783102014Cysteine-rich secretory protein 3 inhibits hepatitis C virus at the initial phase of infection.1
249783102014Cysteine-rich secretory protein 3 inhibits hepatitis C virus at the initial phase of infection.1
231967982013Cysteine-rich secretory protein 3 overexpression is linked to a subset of PTEN-deleted ERG fusion-positive prostate cancers with early biochemical recurrence.14
233757212013Mapping of the binding sites involved in PSP94-CRISP-3 interaction by molecular dissection of the complex.3
231967982013Cysteine-rich secretory protein 3 overexpression is linked to a subset of PTEN-deleted ERG fusion-positive prostate cancers with early biochemical recurrence.14
233757212013Mapping of the binding sites involved in PSP94-CRISP-3 interaction by molecular dissection of the complex.3
229933492012The expression of β-microseminoprotein but not CRISP3 is reduced in ovarian cancer and correlates to survival.3

Citation

Dessen P

CRISP3 (cysteine rich secretory protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46180