CCL16 (C-C motif chemokine ligand 16)

2007-02-01  

Identity

HGNC
CCL16
LOCATION
17q12
LOCUSID
6360
ALIAS
CKb12,HCC-4,ILINCK,LCC-1,LEC,LMC,Mtn-1,NCC-4,NCC4,SCYA16,SCYL4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6360
MIM: 601394
HGNC: 10614
Ensembl: ENSG00000275152

Variants:

dbSNP: 6360
ClinVar: 6360
TCGA: ENSG00000275152
COSMIC: CCL16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000275152ENST00000610493A0A087WUU4
ENSG00000275152ENST00000611905O15467
ENSG00000275152ENST00000613642A0A087WUE5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
382748052023Characterizing ligand-receptor interactions and unveiling the pro-tumorigenic role of CCL16-CCR1 axis in the microenvironment of hepatocellular carcinoma.1
382748052023Characterizing ligand-receptor interactions and unveiling the pro-tumorigenic role of CCL16-CCR1 axis in the microenvironment of hepatocellular carcinoma.1
363589372022Structure and Dynamics of Human Chemokine CCL16-Implications for Biological Activity.1
363589372022Structure and Dynamics of Human Chemokine CCL16-Implications for Biological Activity.1
335007262021CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis.15
335007262021CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis.15
319488402020CC motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells.9
319488402020CC motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells.9
273573962016Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels.1
273573962016Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels.1
228578682012Umbilical artery chemokine CCL16 is associated with preterm preeclampsia and fetal growth restriction.15
228578682012Umbilical artery chemokine CCL16 is associated with preterm preeclampsia and fetal growth restriction.15
212887362011Cord blood chemokines differentiate between spontaneous and elective preterm births in singleton pregnancies.3
219518092011Pro-inflammatory chemokine C-C motif ligand 16 (CCL-16) dysregulation in irritable bowel syndrome (IBS): a pilot study.10
212887362011Cord blood chemokines differentiate between spontaneous and elective preterm births in singleton pregnancies.3

Citation

Dessen P

CCL16 (C-C motif chemokine ligand 16)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46181