TTF1 (transcription termination factor 1)

2007-02-01  

Identity

HGNC
TTF1
LOCATION
9q34.13
LOCUSID
7270
ALIAS
TTF-1,TTF-I
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7270
MIM: 600777
HGNC: 12397
Ensembl: ENSG00000125482

Variants:

dbSNP: 7270
ClinVar: 7270
TCGA: ENSG00000125482
COSMIC: TTF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125482ENST00000334270Q15361
ENSG00000125482ENST00000334270A0A024R8C1
ENSG00000125482ENST00000612514A0A087WY09

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Metabolism of proteinsREACTOMER-HSA-392499
DiseaseREACTOMER-HSA-1643685
Diseases of metabolismREACTOMER-HSA-5668914
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Diseases associated with surfactant metabolismREACTOMER-HSA-5687613
Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)REACTOMER-HSA-5688031
Surfactant metabolismREACTOMER-HSA-5683826
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
341429522022Exploring immunoreactivity of TTF-1 and AVP in hypothalamic hamartoma.0
348718012022TTF-1: A Well-Favored Addition to the Immunohistochemistry Armamentarium as a Diagnostic Marker of SEGA.1
341429522022Exploring immunoreactivity of TTF-1 and AVP in hypothalamic hamartoma.0
348718012022TTF-1: A Well-Favored Addition to the Immunohistochemistry Armamentarium as a Diagnostic Marker of SEGA.1
291041092018Aberrant expression of thyroid transcription factor-1 in schwannomas.4
295550142018Investigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replication.0
296586092018Survivin knockdown induces senescence in TTF‑1-expressing, KRAS-mutant lung adenocarcinomas.9
301942072018TTF-1 Expression Predicts the Merit of Additional Antiangiogenic Treatment in Non-squamous Non-small Cell Lung Cancer.7
303487182018Prognostic Value of Thyroid Transcription Factor-1 Expression in Patients with Advanced Lung Adenocarcinoma.5
291041092018Aberrant expression of thyroid transcription factor-1 in schwannomas.4
295550142018Investigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replication.0
296586092018Survivin knockdown induces senescence in TTF‑1-expressing, KRAS-mutant lung adenocarcinomas.9
301942072018TTF-1 Expression Predicts the Merit of Additional Antiangiogenic Treatment in Non-squamous Non-small Cell Lung Cancer.7
303487182018Prognostic Value of Thyroid Transcription Factor-1 Expression in Patients with Advanced Lung Adenocarcinoma.5
282468832017Novel linkage disequilibrium clustering algorithm identifies new lupus genes on meta-analysis of GWAS datasets.4

Citation

Dessen P

TTF1 (transcription termination factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46184