PCDH10 (protocadherin 10)

2007-02-01  

Identity

HGNC
PCDH10
LOCATION
4q28.3
LOCUSID
57575
ALIAS
OL-PCDH,PCDH19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57575
MIM: 608286
HGNC: 13404
Ensembl: ENSG00000138650

Variants:

dbSNP: 57575
ClinVar: 57575
TCGA: ENSG00000138650
COSMIC: PCDH10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138650ENST00000264360Q9P2E7
ENSG00000138650ENST00000264360X5D999
ENSG00000138650ENST00000618019Q9P2E7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365389832023Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.5
370582522023The role of Pcdh10 in neurological disease and cancer.5
371477332023E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1.4
365389832023Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.5
370582522023The role of Pcdh10 in neurological disease and cancer.5
371477332023E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1.4
332712632021PCDH10 exerts tumor-suppressor functions through modulation of EGFR/AKT axis in colorectal cancer.10
335277912021HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma.12
332712632021PCDH10 exerts tumor-suppressor functions through modulation of EGFR/AKT axis in colorectal cancer.10
335277912021HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma.12
316516842020Quantitation Analysis of PCDH10 Methylation in Adolescent Idiopathic Scoliosis Using Pyrosequencing Study.9
325355942020Disruption of PCDH10 and TNRC18 Genes due to a Balanced Translocation.1
316516842020Quantitation Analysis of PCDH10 Methylation in Adolescent Idiopathic Scoliosis Using Pyrosequencing Study.9
325355942020Disruption of PCDH10 and TNRC18 Genes due to a Balanced Translocation.1
310884132019High methylation levels of PCDH10 predict poor prognosis in patients with pancreatic ductal adenocarcinoma.11

Citation

Dessen P

PCDH10 (protocadherin 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46192/pcdh10