DRD2 (dopamine receptor D2)

2007-02-01 Affiliation

Identity

HGNC

DRD2

LOCATION

11q23.2

LOCUSID

1813

ALIAS

D2DR,D2R

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1813
MIM: 126450
HGNC: 3023
Ensembl: ENSG00000149295

Variants:

dbSNP: 1813
ClinVar: 1813
TCGA: ENSG00000149295
COSMIC: DRD2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149295	ENST00000346454	P14416
ENSG00000149295	ENST00000346454	A0A024R3I6
ENSG00000149295	ENST00000362072	P14416
ENSG00000149295	ENST00000362072	A0A024R3C5
ENSG00000149295	ENST00000538967	P14416
ENSG00000149295	ENST00000542616	A0A1Y8EK52
ENSG00000149295	ENST00000542968	P14416
ENSG00000149295	ENST00000542968	A0A024R3C5
ENSG00000149295	ENST00000543292	Q6LDH7
ENSG00000149295	ENST00000544518	F8VUV1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Gap junction	KEGG	ko04540
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Gap junction	KEGG	hsa04540
Parkinson's disease	KEGG	hsa05012
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Dopamine receptors	REACTOME	R-HSA-390651
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10026	aripiprazole	Chemical	ClinicalAnnotation, VipGene	associated		PD	11505224, 11920858, 14610521, 15567074, 15694263, 15830237, 16123753, 16513877, 16973280, 17087792, 17105675, 18583979, 18687376, 18926547, 19158809, 19582781, 19900188, 9713903, 9858029, 991813, 10327430, 11505224, 15694263, 15830237, 16513877, 17105675, 18926547, 20194480, 28673279, 9858029, 9918131
PA128406954	Weight gain	Disease	ClinicalAnnotation	associated		PD	17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA151186253	nemonapride	Chemical	ClinicalAnnotation, VipGene	associated		PD	10823405, 10862524, 11329406, 11505224, 12587665, 15077009, 15146457, 15184239, 15286066, 15492764, 15830237, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 10395223, 11505224, 15694263, 15830237, 16513877, 17105675, 18926547, 20194480, 28673279, 9858029, 9918131
PA162565877	amisulpride	Chemical	ClinicalAnnotation	associated		PD	25679126
PA164712362	Analgesics	Chemical	ClinicalAnnotation	associated			25096645
PA164712462	Antiinflammatory agents, non-steroids	Chemical	ClinicalAnnotation	associated			25096645
PA164712741	Ergot alkaloids	Chemical	ClinicalAnnotation	associated			25096645
PA164713257	Selective serotonin reuptake inhibitors	Chemical	ClinicalAnnotation	associated		PD	22796099
PA164749035	ropinirole	Chemical	VipGene	associated			18808942
PA164764584	rasagiline	Chemical	ClinicalAnnotation	associated		PD	27190009
PA165282097	bromperidol	Chemical	ClinicalAnnotation, VipGene	associated		PD	11505224, 15694263, 15830237, 16513877, 17105675, 18926547, 20194480, 28673279, 9858029, 9918131
PA166123368	schizoaffective disorder	Disease	ClinicalAnnotation	associated		PD
PA166154261	rs6277	Variant	VipGene	associated			16123753, 16973280, 17087792, 18583979, 18687376, 18926547, 19158809, 19582781, 19900188, 15567074
PA166154334	rs1799732	Variant	VipGene	associated			11920858, 14610521, 15694263, 15830237, 16123753, 16513877, 17105675, 18926547, 9713903, 9858029, 991813, 11505224
PA166154339	rs1800497	Variant	VipGene	associated			10823405, 10862524, 11329406, 12587665, 15077009, 15146457, 15184239, 15286066, 15492764, 15830237, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 10395223
PA166154341	rs1801028	Variant	VipGene	associated			12707934, 7907680, 7909081, 8723039, 8824240, 9650635, 11011590
PA443309	Alcoholism	Disease	ClinicalAnnotation	associated		PD	10490697, 11054774, 17989061, 1839129, 1969501, 1979357, 27447243, 29236941, 8033754
PA443842	Death	Disease	ClinicalAnnotation	associated		PD	29236941
PA444460	Heroin Dependence	Disease	ClinicalAnnotation	associated	PK	PD	19373123, 21902500, 23651024
PA444545	Hyperprolactinemia	Disease	ClinicalAnnotation	associated		PD	17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation	associated		PD	11054774, 19373123, 23651024, 25500252
PA445048	Nausea	Disease	ClinicalAnnotation	associated		PD	24360851
PA445254	Parkinson Disease	Disease	ClinicalAnnotation, VipGene	associated		PD	9457173, 16485914, 27190009, 27779245
PA445452	Psychomotor Agitation	Disease	ClinicalAnnotation	associated		PD
PA445876	Tobacco Use Disorder	Disease	ClinicalAnnotation, VipGene	associated		PD	15203796, 16123753
PA446876	Substance-Related Disorders	Disease	ClinicalAnnotation	associated		PD	18687376, 25556837, 8033754
PA446878	Cocaine-Related Disorders	Disease	ClinicalAnnotation	associated		PD	23635803
PA447197	Attention Deficit Disorder with Hyperactivity	Disease	ClinicalAnnotation	associated		PD	26810137
PA447199	Bipolar Disorder	Disease	ClinicalAnnotation	associated	PK		21095016
PA447208	Mental Disorders	Disease	ClinicalAnnotation	associated		PD	22967772
PA447215	Psychotic Disorders	Disease	ClinicalAnnotation	associated		PD	18086475, 18579277, 20664489, 21749219, 27272046
PA447216	Schizophrenia	Disease	ClinicalAnnotation, VipGene	associated		PD	16973280, 17087792, 18583979, 19158809, 8723039, 9097961, 9209827, 11505224, 12707934, 15694263, 15830237, 16513877, 17105675, 18855532, 18926547, 20194480, 20375926, 20714340, 25563748, 25679126, 28673279, 9858029, 9918131
PA447268	tardive dyskinesia	Disease	ClinicalAnnotation	associated		PD	17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA447278	Depression	Disease	ClinicalAnnotation	associated	PK		21095016
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated		PD	22796099
PA448073	ethanol	Chemical	ClinicalAnnotation	associated		PD	10490697, 11054774, 17989061, 1839129, 1969501, 1979357, 22798433, 27447243, 29236941, 8033754
PA448408	amphetamine	Chemical	ClinicalAnnotation	associated		PD
PA448687	bupropion	Chemical	ClinicalAnnotation, VipGene	associated		PD	10823405, 10862524, 11329406, 12587665, 15077009, 15146457, 15184239, 15286066, 15492764, 15830237, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 10395223, 16123753
PA448708	cabergoline	Chemical	VipGene	associated			18808942
PA448964	chlorpromazine	Chemical	ClinicalAnnotation, VipGene	associated		PD	11505224, 15694263, 15830237, 16513877, 17105675, 18926547, 20194480, 28673279, 9858029, 9918131
PA449061	clozapine	Chemical	ClinicalAnnotation, VipGene	associated		PD	11920858, 14610521, 15694263, 15830237, 16123753, 16513877, 17105675, 18926547, 9713903, 9858029, 991813, 11505224, 15694263, 15830237, 16513877, 17105675, 17767146, 18086475, 18180754, 18579277, 18926547, 20194480, 20375926, 20714340, 23851570, 23859574, 26872113, 28673279, 9858029, 9918131
PA449072	cocaine	Chemical	ClinicalAnnotation	associated		PD
PA449376	disulfiram	Chemical	ClinicalAnnotation	associated		PD	23635803
PA449841	haloperidol	Chemical	MultilinkAnnotation, VipGene	associated			10823405, 10862524, 11329406, 12587665, 15077009, 15146457, 15184239, 15286066, 15492764, 15830237, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 10395223, 27023437
PA450213	levodopa	Chemical	ClinicalAnnotation	associated		PD	27779245
PA450401	methadone	Chemical	ClinicalAnnotation	associated	PK	PD	18687376, 19373123, 21902500, 23651024, 25556837
PA450464	methylphenidate	Chemical	ClinicalAnnotation	associated		PD	26810137
PA450626	nicotine	Chemical	ClinicalAnnotation	associated		PD	15203796, 16123753
PA450688	olanzapine	Chemical	ClinicalAnnotation, VipGene	associated	PK	PD	11920858, 14610521, 15694263, 15830237, 16123753, 16513877, 17105675, 18926547, 9713903, 9858029, 991813, 11505224, 15694263, 15830237, 16513877, 17105675, 17767146, 18086475, 18180754, 18579277, 18926547, 20194480, 20375926, 20714340, 21095016, 22967772, 23851570, 23859574, 25563748, 26872113, 28673279, 9858029, 9918131
PA450873	pergolide	Chemical	VipGene	associated			18808942
PA451114	prochlorperazine	Chemical	ClinicalAnnotation	associated		PD	24360851
PA451257	risperidone	Chemical	ClinicalAnnotation, VipGene	associated		PD	10823405, 10862524, 11329406, 11505224, 11920858, 12587665, 14610521, 15077009, 15146457, 15184239, 15286066, 15492764, 15694263, 15830237, 16123753, 16513877, 17105675, 17767146, 17989061, 18086475, 18180754, 18354387, 1839129, 18781856, 18781857, 18855532, 18926547, 19179847, 19273465, 19373123, 19396436, 19603545, 1969501, 19853839, 19944883, 9672901, 9713903, 9858029, 991813, 10395223, 11505224, 15694263, 15830237, 16513877, 17105675, 17767146, 18086475, 18180754, 18579277, 18855532, 18926547, 20194480, 20375926, 20714340, 23851570, 23859574, 26872113, 28673279, 9858029, 9918131
PA451566	sumatriptan	Chemical	ClinicalAnnotation	associated			25096645
PA452233	antipsychotics	Chemical	ClinicalAnnotation, VipGene	associated		PD	11505224, 15694263, 15830237, 16513877, 17105675, 17767146, 18086475, 18180754, 18579277, 18926547, 20194480, 20664489, 20714340, 21749219, 23851570, 23859574, 26872113, 27272046, 28673279, 9209827, 9858029, 9918131
PA452618	opioids	Chemical	ClinicalAnnotation	associated		PD	11054774, 19373123, 25096645, 25500252
PA452619	heroin	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
37400684	2024	DRD2 TaqIA polymorphism-related functional connectivity between anterior insula and dorsolateral prefrontal cortex predicts the retention time in heroin-dependent individuals under methadone maintenance treatment.	0
37578679	2024	Gene Interaction of Dopaminergic Synaptic Pathway Genes in Attention-Deficit Hyperactivity Disorder: a Case-Control Study in Chinese Children.	1
37752366	2024	Subcutaneous adipose tissue dopamine D2 receptor is increased in prediabetes and T2D.	1
38749085	2024	The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms.	0
37400684	2024	DRD2 TaqIA polymorphism-related functional connectivity between anterior insula and dorsolateral prefrontal cortex predicts the retention time in heroin-dependent individuals under methadone maintenance treatment.	0
37578679	2024	Gene Interaction of Dopaminergic Synaptic Pathway Genes in Attention-Deficit Hyperactivity Disorder: a Case-Control Study in Chinese Children.	1
37752366	2024	Subcutaneous adipose tissue dopamine D2 receptor is increased in prediabetes and T2D.	1
38749085	2024	The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms.	0
34524581	2023	Impact on the Risk and Severity of Childhood Onset Schizophrenia of Schizophrenia Risk Genetic Variants at the DRD2 and ZNF804A Loci.	3
36437548	2023	The ANKK1/DRD2 gene TaqIA polymorphism (rs1800497) is associated with the severity of extrapyramidal side effects of haloperidol treatment in CYP2D6 extensive metabolizers with schizophrenia spectrum disorders.	1
36456191	2023	Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in Mice Carrying the Human Pathogenic Mutation DRD2(I212F).	1
36710462	2023	Striatal dopamine D2 receptor availability as a predictor of subsequent alcohol use in social drinkers.	0
36740143	2023	Assessment of genetic variants in D2 dopamine receptor (DRD2) gene as risk factors for post-traumatic stress disorder (PTSD) and major depressive disorder (MDD): A systematic review and meta-analysis.	2
36747480	2023	Comparing DRD2 Promoter Methylation Between Blood and Brain in Alcohol Dependence.	0
36805080	2023	The Addiction-Susceptibility TaqIA/Ankk1 Controls Reward and Metabolism Through D(2) Receptor-Expressing Neurons.	2

Citation

Dessen P

DRD2 (dopamine receptor D2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46193