CCR10 (C-C motif chemokine receptor 10)

2007-02-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
GPR2

Other Information

Locus ID:

NCBI: 2826
MIM: 600240
HGNC: 4474
Ensembl: ENSG00000184451

Variants:

dbSNP: 2826
ClinVar: 2826
TCGA: ENSG00000184451
COSMIC: CCR10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184451ENST00000332438P46092
ENSG00000184451ENST00000591568K7EPC9
ENSG00000184451ENST00000591765K7ER70

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384298442024Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway.0
384298442024Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway.0
361691162023The CCL27-CCR10 axis contributes to promoting proliferation, migration, and invasion of lung squamous cell carcinoma.1
372224802023Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa.2
361691162023The CCL27-CCR10 axis contributes to promoting proliferation, migration, and invasion of lung squamous cell carcinoma.1
372224802023Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa.2
358999922022Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes.3
358999922022Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes.3
327737692021Coordinated co-migration of CCR10(+) antibody-producing B cells with helper T cells for colonic homeostatic regulation.6
345648532021SARS-CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10.11
327737692021Coordinated co-migration of CCR10(+) antibody-producing B cells with helper T cells for colonic homeostatic regulation.6
345648532021SARS-CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10.11
304753882019CCR10(+) ILC2s with ILC1-like properties exhibit a protective function in severe allergic asthma.10
304753882019CCR10(+) ILC2s with ILC1-like properties exhibit a protective function in severe allergic asthma.10
294451902018The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.25

Citation

Dessen P

CCR10 (C-C motif chemokine receptor 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46203/ccr10