UCK2 (uridine-cytidine kinase 2)

2007-02-01  

Identity

HGNC
UCK2
LOCATION
1q24.1
LOCUSID
7371
ALIAS
TSA903,UK,UMPK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7371
MIM: 609329
HGNC: 12562
Ensembl: ENSG00000143179

Variants:

dbSNP: 7371
ClinVar: 7371
TCGA: ENSG00000143179
COSMIC: UCK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143179ENST00000367879Q9BZX2
ENSG00000143179ENST00000367879A0A024R912
ENSG00000143179ENST00000469256Q9BZX2
ENSG00000143179ENST00000470820Q9BZX2
ENSG00000143179ENST00000642653A0A2R8Y653

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Drug metabolism - other enzymesKEGGko00983
Pyrimidine metabolismKEGGhsa00240
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine salvage reactionsREACTOMER-HSA-73614

References

Pubmed IDYearTitleCitations
375347912023Cytotoxic Flavokawain B Inhibits the Growth and Metastasis of Hepatocellular Carcinoma through UCK2 Modulation of the STAT3/Hif-1α/VEGF Signalling Pathway.2
375347912023Cytotoxic Flavokawain B Inhibits the Growth and Metastasis of Hepatocellular Carcinoma through UCK2 Modulation of the STAT3/Hif-1α/VEGF Signalling Pathway.2
364471382022Targeting uridine-cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma.5
364471382022Targeting uridine-cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma.5
303045692019UCK2 upregulation might serve as an indicator of unfavorable prognosis of hepatocellular carcinoma.21
305566102019Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.20
312788862019Uridine-cytidine kinase 2 (UCK2): A potential diagnostic and prognostic biomarker for lung cancer.24
303045692019UCK2 upregulation might serve as an indicator of unfavorable prognosis of hepatocellular carcinoma.21
305566102019Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.20
312788862019Uridine-cytidine kinase 2 (UCK2): A potential diagnostic and prognostic biomarker for lung cancer.24
272397012016The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma.14
276122032016The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.9
279066292016Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines.5
272397012016The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma.14
276122032016The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.9

Citation

Dessen P

UCK2 (uridine-cytidine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46207