HPSE2 (heparanase 2 (inactive))

2007-02-01  

Identity

HGNC
LOCATION
10q24.2
LOCUSID
ALIAS
HPA2,HPR2,UFS,UFS1
FUSION GENES

Other Information

Locus ID:

NCBI: 60495
MIM: 613469
HGNC: 18374
Ensembl: ENSG00000172987

Variants:

dbSNP: 60495
ClinVar: 60495
TCGA: ENSG00000172987
COSMIC: HPSE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172987ENST00000370546Q8WWQ2
ENSG00000172987ENST00000370549Q8WWQ2
ENSG00000172987ENST00000370552Q8WWQ2
ENSG00000172987ENST00000404542A0A0A0MSB9
ENSG00000172987ENST00000614306A0A087X238
ENSG00000172987ENST00000628193Q8WWQ2

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Glycosaminoglycan degradationKEGGko00531
Glycosaminoglycan degradationKEGGhsa00531
Metabolic pathwaysKEGGhsa01100
Heparan sulfate degradationKEGGhsa_M00078
Heparan sulfate degradationKEGGM00078
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG degradationREACTOMER-HSA-2024096

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385194562024Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis.0
389902082024Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome.0
385194562024Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis.0
389902082024Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome.0
369802542023Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma.0
369802542023Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma.0
348083352022Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3.5
361228212022Heparanase 2 (Hpa2) attenuates the growth of human sarcoma.4
348083352022Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3.5
361228212022Heparanase 2 (Hpa2) attenuates the growth of human sarcoma.4
336635222021Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis.9
338392212021Heparanase 2 (Hpa2) attenuates the growth of pancreatic carcinoma.7
340043532021Heparanase 2 (Hpa2) attenuates tumor growth by inducing Sox2 expression.9
343438222021Role of heparanase 2 (Hpa2) in gastric cancer.6
336635222021Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis.9

Citation

Dessen P

HPSE2 (heparanase 2 (inactive))

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46219/favicon/meetings/