Identity
HGNC
LOCATION
3q27.2
LOCUSID
ALIAS
IMP-2,IMP2,VICKZ2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10644
MIM: 608289
HGNC: 28867
Ensembl: ENSG00000073792
Variants:
dbSNP: 10644
ClinVar: 10644
TCGA: ENSG00000073792
COSMIC: IGF2BP2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000073792 | ENST00000346192 | Q9Y6M1 |
| ENSG00000073792 | ENST00000382199 | Q9Y6M1 |
| ENSG00000073792 | ENST00000421047 | Q9Y6M1 |
| ENSG00000073792 | ENST00000457616 | F8W930 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | REACTOME | R-HSA-428359 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443890 | Diabetes Mellitus, Type 2 | Disease | ClinicalAnnotation | associated | PD | ||
| PA451234 | repaglinide | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37647879 | 2024 | CircEXOC5 Aggravates Sepsis-Induced Acute Lung Injury by Promoting Ferroptosis Through the IGF2BP2/ATF3 Axis. | 0 |
| 37917979 | 2024 | The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA. | 0 |
| 38102465 | 2024 | m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma. | 0 |
| 38122949 | 2024 | Pancancer analysis uncovers an immunological role and prognostic value of the m6A reader IGF2BP2 in pancreatic cancer. | 0 |
| 38250159 | 2024 | IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer. | 1 |
| 38287808 | 2024 | Gene Editing and Small Molecule Inhibitors of the RNA Binding Protein IGF2BP2/IMP2 Show its Potential as an Anti-Cancer Drug Target. | 1 |
| 38319733 | 2024 | METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2. | 1 |
| 38383230 | 2024 | The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750. | 0 |
| 38443991 | 2024 | KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma. | 1 |
| 38468402 | 2024 | IGF2BP2 and IGFBP3 Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome. | 0 |
| 38572589 | 2024 | m(6)A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia. | 1 |
| 38701040 | 2024 | The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study. | 0 |
| 38703029 | 2024 | Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway. | 0 |
| 38937789 | 2024 | The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages. | 0 |
| 37647879 | 2024 | CircEXOC5 Aggravates Sepsis-Induced Acute Lung Injury by Promoting Ferroptosis Through the IGF2BP2/ATF3 Axis. | 0 |
Citation
Dessen P
IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46232/igf2bp2
