Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54578
MIM: 606431
HGNC: 12538
Ensembl: ENSG00000167165
Variants:
dbSNP: 54578
ClinVar: 54578
TCGA: ENSG00000167165
COSMIC: UGT1A6
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA130620651 | anthracyclines and related substances | Chemical | ClinicalAnnotation | associated | PD | 21900104, 23441093 | |
| PA131285527 | oxaliplatin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 23963147 | |
| PA165110775 | SN-38 | Chemical | Pathway | associated | |||
| PA165958521 | febuxostat | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA166115442 | s 1 (combination) | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 23963147 | |
| PA166118041 | deferiprone | Chemical | ClinicalAnnotation | associated | PD | 24036429 | |
| PA420 | UGT1A1 | Gene | VipGene | associated | 11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366 | ||
| PA443756 | Colonic Neoplasms | Disease | ClinicalAnnotation | associated | PD | ||
| PA443937 | Drug Toxicity | Disease | VariantAnnotation | not associated | PD | ||
| PA444065 | Epilepsy | Disease | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 15761113, 21806385, 23099353, 28763744 |
| PA444318 | Gout | Disease | ClinicalAnnotation | associated | PD | 27798726 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 21900104, 23441093 | |
| PA445601 | Osteosarcoma | Disease | ClinicalAnnotation | associated | PK | 29791011 | |
| PA446051 | Vomiting | Disease | VariantAnnotation | associated | PD | ||
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 23386248, 23963147 | |
| PA446432 | beta-Thalassemia | Disease | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 17164591, 24036429 |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA448015 | acetaminophen | Chemical | Literature, MultilinkAnnotation, Pathway, VariantAnnotation | associated | PK | 11714888, 15761113, 16696573, 17164591, 23279026, 23462933, 26049587 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449212 | daunorubicin | Chemical | GuidelineAnnotation | associated | |||
| PA449412 | doxorubicin | Chemical | GuidelineAnnotation | associated | |||
| PA450085 | irinotecan | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 23386248, 23963147 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PK | 29791011 | |
| PA450911 | phenobarbital | Chemical | Pathway | associated | 26049587 | ||
| PA450947 | phenytoin | Chemical | Pathway | associated | 26049587 | ||
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451846 | valproic acid | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 15761113, 21806385, 23099353, 28763744 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37820941 | 2024 | Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy. | 0 |
| 37828659 | 2024 | The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors. | 0 |
| 37820941 | 2024 | Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy. | 0 |
| 37828659 | 2024 | The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors. | 0 |
| 36571650 | 2023 | Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. | 0 |
| 36718958 | 2023 | Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients. | 0 |
| 36571650 | 2023 | Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. | 0 |
| 36718958 | 2023 | Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients. | 0 |
| 36250837 | 2022 | Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy. | 2 |
| 36250837 | 2022 | Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy. | 2 |
| 33400134 | 2021 | UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy. | 3 |
| 34000957 | 2021 | Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children. | 2 |
| 33400134 | 2021 | UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy. | 3 |
| 34000957 | 2021 | Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children. | 2 |
| 30686291 | 2019 | A meta-analysis of the influence of UGT1A6 genetic polymorphisms on valproic acid pharmacokinetics . | 5 |
Citation
Dessen P
UGT1A6 (UDP glucuronosyltransferase family 1 member A6)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46238/ugt1a6
