CHST4 (carbohydrate sulfotransferase 4)

2007-02-01 Affiliation

Identity

HGNC

CHST4

LOCATION

16q22.2

LOCUSID

10164

ALIAS

GST3,GlcNAc6ST2,HECGLCNAC6ST,LSST

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10164
HGNC: 1972
Ensembl: ENSG00000140835

Variants:

dbSNP: 10164
ClinVar: 10164
TCGA: ENSG00000140835
COSMIC: CHST4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140835	ENST00000338482	Q8NCG5
ENSG00000140835	ENST00000539698	Q8NCG5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	ko00533
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	hsa00533
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
O-linked glycosylation	REACTOME	R-HSA-5173105
O-linked glycosylation of mucins	REACTOME	R-HSA-913709

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
30093410	2018	Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis.	12
30093410	2018	Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis.	12
27748735	2016	Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma.	13
27748735	2016	Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma.	13
24799377	2014	Detecting O-GlcNAc using in vitro sulfation.	4
24799377	2014	Detecting O-GlcNAc using in vitro sulfation.	4
19156517	2009	N-Acetylglucosamine 6-O-sulfotransferase-2 as a tumor marker for uterine cervical and corpus cancer.	6
19343046	2009	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	4
19156517	2009	N-Acetylglucosamine 6-O-sulfotransferase-2 as a tumor marker for uterine cervical and corpus cancer.	6
19343046	2009	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	4
12107080	2002	Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma.	9
12218059	2002	Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.	17
12107080	2002	Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma.	9
12218059	2002	Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.	17

Citation

Dessen P

CHST4 (carbohydrate sulfotransferase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46239