USP2 (ubiquitin specific peptidase 2)

2007-02-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
UBP41,USP9
FUSION GENES

Other Information

Locus ID:

NCBI: 9099
MIM: 604725
HGNC: 12618
Ensembl: ENSG00000036672

Variants:

dbSNP: 9099
ClinVar: 9099
TCGA: ENSG00000036672
COSMIC: USP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000036672ENST00000260187O75604
ENSG00000036672ENST00000455332O75604
ENSG00000036672ENST00000525735O75604
ENSG00000036672ENST00000527843E9PJ34
ENSG00000036672ENST00000531070E9PSH6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Expression and DegradationREACTOMER-HSA-6806003
Regulation of TP53 DegradationREACTOMER-HSA-6804757
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377270112024Age-related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis.0
377270112024Age-related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis.0
351528552022Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway.1
353322682022Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-β signaling.9
353848812022High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma.0
355047262022Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation.3
365679032022USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination.3
351528552022Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway.1
353322682022Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-β signaling.9
353848812022High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma.0
355047262022Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation.3
365679032022USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination.3
330744772021Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A.10
335822172021Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21.8
344251072021USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates.9

Citation

Dessen P

USP2 (ubiquitin specific peptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46243/usp2