EFNB3 (ephrin B3)

2007-02-01  

Identity

HGNC
EFNB3
LOCATION
17p13.1
LOCUSID
1949
ALIAS
EFL6,EPLG8,LERK8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1949
MIM: 602297
HGNC: 3228
Ensembl: ENSG00000108947

Variants:

dbSNP: 1949
ClinVar: 1949
TCGA: ENSG00000108947
COSMIC: EFNB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108947ENST00000226091Q15768

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Ephrin signalingREACTOMER-HSA-3928664
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381428372024Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer.1
381428372024Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer.1
310118592019Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling.12
310118592019Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling.12
299538582018Ephrin-B3 binds both cell-associated and secreted proteoglycans.1
302629192018Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with hypertension risks in males with hypogonadism.4
299538582018Ephrin-B3 binds both cell-associated and secreted proteoglycans.1
302629192018Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with hypertension risks in males with hypogonadism.4
282725172017Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene.5
282725172017Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene.5
266879802016Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.21
269306152016Up-regulated ephrinB3/EphB3 expression in intractable temporal lobe epilepsy patients and pilocarpine induced experimental epilepsy rat model.9
275330872016Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer.15
279419042016The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility.10
266879802016Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.21

Citation

Dessen P

EFNB3 (ephrin B3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46244