ERAP2 (endoplasmic reticulum aminopeptidase 2)

2007-02-01  

Identity

HGNC
ERAP2
LOCATION
5q15
LOCUSID
64167
ALIAS
L-RAP,LRAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64167
MIM: 609497
HGNC: 29499
Ensembl: ENSG00000164308

Variants:

dbSNP: 64167
ClinVar: 64167
TCGA: ENSG00000164308
COSMIC: ERAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164308ENST00000379904Q6P179
ENSG00000164308ENST00000437043Q6P179
ENSG00000164308ENST00000507346D6RF46
ENSG00000164308ENST00000508077H0YAL8
ENSG00000164308ENST00000510309Q6P179
ENSG00000164308ENST00000510373D6RGW0
ENSG00000164308ENST00000512869H0Y9X9
ENSG00000164308ENST00000513084Q6P179

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381900992024A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs.2
387047852024A study of the association between single nucleotide polymorphisms of the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene and the risk of ankylosing spondylitis in Egyptians.0
381900992024A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs.2
387047852024A study of the association between single nucleotide polymorphisms of the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene and the risk of ankylosing spondylitis in Egyptians.0
366084222023ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes.2
367169172023Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.4
368348652023A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2.2
376861412023ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes.0
366084222023ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes.2
367169172023Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.4
368348652023A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2.2
376861412023ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes.0
346421122022ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway.7
362147622022ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer.4
365698282022The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities.2

Citation

Dessen P

ERAP2 (endoplasmic reticulum aminopeptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46264/favicon/haematological-explorer/haematological-explorer/