Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3795
MIM: 614058
HGNC: 6315
Ensembl: ENSG00000138030
Variants:
dbSNP: 3795
ClinVar: 3795
TCGA: ENSG00000138030
COSMIC: KHK
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000138030 | ENST00000260598 | P50053 |
| ENSG00000138030 | ENST00000260599 | P50053 |
| ENSG00000138030 | ENST00000260599 | A0A140VJM6 |
| ENSG00000138030 | ENST00000429697 | C9JDL1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA449716 | fructose | Chemical | Pathway | associated | 24915143 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37230214 | 2023 | Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD. | 2 |
| 37230214 | 2023 | Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD. | 2 |
| 35133629 | 2022 | USP36 promotes tumor growth of non-small cell lung cancer via increasing KHK-A expression by regulating c-MYC-hnRNPH1/H2 axis. | 6 |
| 35257833 | 2022 | GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. | 12 |
| 35133629 | 2022 | USP36 promotes tumor growth of non-small cell lung cancer via increasing KHK-A expression by regulating c-MYC-hnRNPH1/H2 axis. | 6 |
| 35257833 | 2022 | GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. | 12 |
| 32928708 | 2021 | KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1. | 3 |
| 33621267 | 2021 | Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants. | 2 |
| 32928708 | 2021 | KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1. | 3 |
| 33621267 | 2021 | Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants. | 2 |
| 33116123 | 2020 | Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. | 32 |
| 33116123 | 2020 | Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. | 32 |
| 31032410 | 2019 | The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. | 33 |
| 31032410 | 2019 | The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. | 33 |
| 28954733 | 2017 | Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. | 59 |
Citation
Dessen P
KHK (ketohexokinase)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46273/khk
