EN2 (engrailed homeobox 2)

2007-02-01  

Identity

HGNC
EN2
LOCATION
7q36.3
LOCUSID
2020
ALIAS
-

Other Information

Locus ID:

NCBI: 2020
MIM: 131310
HGNC: 3343
Ensembl: ENSG00000164778

Variants:

dbSNP: 2020
ClinVar: 2020
TCGA: ENSG00000164778
COSMIC: EN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164778ENST00000297375P19622

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
379875072024Engrailed 2 serves as a master regulator of the super-enhancer in the TNC gene locus in non-small cell lung cancer.0
379875072024Engrailed 2 serves as a master regulator of the super-enhancer in the TNC gene locus in non-small cell lung cancer.0
351692232022Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer.9
351692232022Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer.9
336853512021Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis.17
336853512021Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis.17
316923912020Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?0
324348692020Bidirectional transfer of homeoprotein EN2 across the plasma membrane requires PIP(2).17
325397632020Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression.1
327328642020EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer.19
316923912020Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?0
324348692020Bidirectional transfer of homeoprotein EN2 across the plasma membrane requires PIP(2).17
325397632020Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression.1
327328642020EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer.19
309147952019Membrane insertion and secretion of the Engrailed-2 (EN2) transcription factor by prostate cancer cells may induce antiviral activity in the stroma.8

Citation

Dessen P

EN2 (engrailed homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46279/case-report-explorer/meetings/tumors-explorer/