Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9970
MIM: 603881
HGNC: 7969
Ensembl: ENSG00000143257
Variants:
dbSNP: 9970
ClinVar: 9970
TCGA: ENSG00000143257
COSMIC: NR1I3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Generic Transcription Pathway | REACTOME | R-HSA-212436 |
| Nuclear Receptor transcription pathway | REACTOME | R-HSA-383280 |
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA123 | CYP2B6 | Gene | Pathway | associated | 21738081 | ||
| PA130 | CYP3A4 | Gene | Pathway | associated | 21738081 | ||
| PA162372840 | sunitinib | Chemical | MultilinkAnnotation | associated | 27561454 | ||
| PA443340 | Anemia | Disease | ClinicalAnnotation | associated | PD | 24193570 | |
| PA445046 | Nasopharyngeal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 24193570 | |
| PA445113 | Neutropenia | Disease | ClinicalAnnotation | associated | PD | 24193570 | |
| PA447230 | HIV | Disease | ClinicalAnnotation | associated | PK | 23172109, 23173844, 24080498 | |
| PA448785 | carbamazepine | Chemical | Pathway | associated | 21738081 | ||
| PA449383 | docetaxel | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 24193570, 27561454 | |
| PA449441 | efavirenz | Chemical | ClinicalAnnotation | associated | PK | 23172109, 23173844, 24080498 | |
| PA451906 | warfarin | Chemical | ClinicalAnnotation | associated | PD | 25356900, 29298995 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38128062 | 2024 | Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation. | 0 |
| 38128062 | 2024 | Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation. | 0 |
| 34504302 | 2022 | Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals. | 2 |
| 35184041 | 2022 | Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development. | 3 |
| 35212371 | 2022 | Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. | 12 |
| 35367211 | 2022 | Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling. | 10 |
| 34504302 | 2022 | Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals. | 2 |
| 35184041 | 2022 | Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development. | 3 |
| 35212371 | 2022 | Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. | 12 |
| 35367211 | 2022 | Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling. | 10 |
| 33333223 | 2021 | Association of xenobiotic receptor polymorphisms with carbamazepine response in epilepsy patients. | 2 |
| 33529650 | 2021 | Role of the constitutive androstane receptor (CAR) in human liver cancer. | 10 |
| 34097921 | 2021 | Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation. | 1 |
| 34502180 | 2021 | Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium. | 2 |
| 33333223 | 2021 | Association of xenobiotic receptor polymorphisms with carbamazepine response in epilepsy patients. | 2 |
Citation
Dessen P
NR1I3 (nuclear receptor subfamily 1 group I member 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46293/nr1i3
